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Substance Name: 1-Butanone, 1-(4-fluorophenyl)-4-(1,4,5,6-tetrahydro-8-hydroxy-6,11-dimethyl-2,6-methano-3-benzazocin-3(2H)-yl)-, (2-alpha,6-alpha,11R*)-
RN: 56390-16-0
InChIKey: SMDNOEGDKSJRPV-XTZPKPCCSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H28-F-N-O2

Molecular Weight

  • 381.4882
 
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Names and Synonyms

Synonyms

  • 2-(3-(p-Fluorobenzoyl)-1-propyl)-5-alpha,9-alpha-dimethyl-2'-hydroxy-6,7-benzomorphan
  • ID-1229

Systematic Name

  • 1-Butanone, 1-(4-fluorophenyl)-4-(1,4,5,6-tetrahydro-8-hydroxy-6,11-dimethyl-2,6-methano-3-benzazocin-3(2H)-yl)-, (2-alpha,6-alpha,11R*)-

Registry Numbers

CAS Registry Number

  • 56390-16-0

System Generated Number

  • 0056390160

Structure Descriptors

InChI

1S/C24H28FNO2/c1-16-22-14-18-7-10-20(27)15-21(18)24(16,2)11-13-26(22)12-3-4-23(28)17-5-8-19(25)9-6-17/h5-10,15-16,22,27H,3-4,11-14H2,1-2H3/t16-,22+,24+/m0/s1

InChIKey

SMDNOEGDKSJRPV-XTZPKPCCSA-N

Smiles

C[C@H]1[C@H]2Cc3ccc(cc3[C@@]1(CCN2CCCC(=O)c4ccc(cc4)F)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 112mg/kg (112mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
mouse LD50 intravenous 32mg/kg (32mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
mouse LD50 oral > 500mg/kg (500mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
mouse LD50 subcutaneous 270mg/kg (270mg/kg) BEHAVIORAL: ATAXIA

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
rabbit LD50 intramuscular > 100mg/kg (100mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
rabbit LD50 intravenous 7850ug/kg (7.85mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
rabbit LD50 subcutaneous 75mg/kg (75mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
rat LD50 intraperitoneal 82mg/kg (82mg/kg) BEHAVIORAL: ATAXIA

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
rat LD50 intravenous 24mg/kg (24mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
rat LD50 oral > 1gm/kg (1000mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.
rat LD50 subcutaneous 520mg/kg (520mg/kg) BEHAVIORAL: ATAXIA

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 795, 1975.