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Substance Name: Trimethoprim sulfate [USAN:USP]
RN: 56585-33-2
UNII: E377MF8EQ8
InChIKey: UILMMYFRNCCPLK-UHFFFAOYSA-N

Note

  • A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

Molecular Formula

  • C14-H18-N4-O3.1/2H2-O4-S

Molecular Weight

  • 678.7202
 

Classification Code

  • Antibacterial

Names and Synonyms

Name of Substance

  • Trimethoprim sulfate [USAN:USP]

Synonyms

  • 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine sulfate (2:1)
  • 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine sulfate (2:1) (salt)
  • 2,4-Pyrimidinediamine, 5-((3,4-trimethoxyphenyl)methyl)-, sulfate (2:1) (salt)
  • BW 72U
  • Trimethoprim sulfate
  • UNII-E377MF8EQ8

Systematic Name

  • 2,4-Pyrimidinediamine, 5-((3,4-trimethoxyphenyl)methyl)-, sulfate (2:1)

Mixture Name

  • Polytrim

Registry Numbers

CAS Registry Number

  • 56585-33-2

FDA UNII

  • E377MF8EQ8

System Generated Number

  • 0056585332

Molecular Formulas

Molecular Formula

  • C14-H18-N4-O3.1/2H2-O4-S

Molecular Formula Fragments

  • C14-H18-N4-O3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C14H18N4O3.H2O4S/c2*1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-5(2,3)4/h2*5-7H,4H2,1-3H3,(H4,15,16,17,18);(H2,1,2,3,4)

InChIKey

UILMMYFRNCCPLK-UHFFFAOYSA-N

Smiles

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC.COc3cc(Cc4cnc(N)nc4N)cc(OC)c3OC.OS(=O)(=O)O