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Substance Name: Spiromustine [USAN:INN]
RN: 56605-16-4
UNII: J3HB83X76Z
InChIKey: QNKJFXARIMSDBR-UHFFFAOYSA-N

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data

Molecular Formula

  • C14-H23-Cl2-N3-O2

Molecular Weight

  • 336.2607
 
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Names and Synonyms

Name of Substance

  • Spiromustine
  • Spiromustine [USAN:INN]

Synonyms

  • 1,3-Diazaspiro(4.5)decane-2,4-dione, 3-(2-(bis(2-chloroethyl)amino)ethyl)-
  • 3-(2-(Bis(2-chloroethyl)amino)ethyl)-1,3-diazaspiro(4.5)decane-2,4-dione
  • 3-(2-(Bis(2-chloroethyl)amino)ethyl)-5,5-pentamethylenehydantoin
  • 5-24-07-00298 (Beilstein Handbook Reference)
  • BRN 0757144
  • NSC 172112
  • NSC-172112
  • Spirohydantoin mustard
  • Spiromustina
  • Spiromustina [INN-Spanish]
  • Spiromustina [Spanish]
  • Spiromustine
  • Spiromustinum
  • Spiromustinum [INN-Latin]
  • UNII-J3HB83X76Z

Systematic Name

  • 1,3-Diazaspiro(4.5)decane-2,4-dione, 3-(2-(bis(2-chloroethyl)amino)ethyl)-

Registry Numbers

CAS Registry Number

  • 56605-16-4

FDA UNII

  • J3HB83X76Z

System Generated Number

  • 0056605164

Structure Descriptors

InChI

1S/C14H23Cl2N3O2/c15-6-8-18(9-7-16)10-11-19-12(20)14(17-13(19)21)4-2-1-3-5-14/h1-11H2,(H,17,21)

InChIKey

QNKJFXARIMSDBR-UHFFFAOYSA-N

Smiles

C1CCC2(CC1)C(=O)N(C(=O)N2)CCN(CCCl)CCCl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3750ug/kg (3.75mg/kg)   National Technical Information Service. Vol. PB83-149518,
dog LDLo intravenous 3750ug/kg (3.75mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)
National Technical Information Service. Vol. PB83-149518,
human TDLo intravenous 243ug/kg/3W-I (0.243mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cancer Research. Vol. 47, Pg. 4213, 1987.
mouse LD50 intraperitoneal 33244ug/kg (33.244mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 intravenous 48280ug/kg (48.28mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER National Technical Information Service. Vol. PB83-148395,
rat LD50 intravenous 9100ug/kg (9.1mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
National Technical Information Service. Vol. PB83-149518,