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Substance Name: Tulobuterol hydrochloride [JAN]
RN: 56776-01-3
UNII: VNC12181T0
InChIKey: RSLNRVYIRDVHLY-UHFFFAOYSA-N

Classification Codes

  • Bronchodilator
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C12-H18-Cl-N-O.Cl-H

Molecular Weight

  • 264.1941
 
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Names and Synonyms

Name of Substance

  • Tulobuterol hydrochloride
  • Tulobuterol hydrochloride [JAN]

Synonyms

  • 1-(o-Chlorophenyl)-2-tert-butylamino ethanol hydrochloride
  • alpha-((tert-Butylamino)methyl)-o-chlorobenzyl alcohol hydrochloride
  • alpha-(tert-Butylamino)methyl-2-chlorobenzyl alcohol hydrochloride
  • Atenos
  • Benzenemethanol, 2-chloro-alpha-(((1,1-dimethylethyl)amino)methyl)-, hydrochloride
  • Benzyl alcohol, alpha-((tert-butylamino)methyl)-o-chloro-, hydrochloride
  • Berachin
  • Brelomax sirup
  • C 78
  • C-78
  • Chlobamol hydrochloride
  • Hokunalin
  • Lobuterol
  • o-Chloro-alpha-((tert-butylamino)methyl)benzylalcohol hydrochloride
  • Tulobuterol HCl
  • Tulobuterol hydrochloride
  • UNII-VNC12181T0

Systematic Name

  • Benzyl alcohol, alpha-(tert-butylamino)methyl-2-chloro-, hydrochloride

Registry Numbers

CAS Registry Number

  • 56776-01-3

FDA UNII

  • VNC12181T0

Other Registry Number

  • 99798-69-3

Related Registry Number

  • 41570-61-0 (Parent)

System Generated Number

  • 0056776013

Molecular Formulas

Molecular Formula

  • C12-H18-Cl-N-O.Cl-H

Molecular Formula Fragments

  • C12-H18-Cl-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H18ClNO.ClH/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13;/h4-7,11,14-15H,8H2,1-3H3;1H

InChIKey

RSLNRVYIRDVHLY-UHFFFAOYSA-N

Smiles

CC(C)(C)NCC(c1ccccc1Cl)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 45mg/kg (45mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.
dog LD50 oral 300mg/kg (300mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1439, 1977.
dog LD50 subcutaneous 150mg/kg (150mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.
mouse LD50 intraperitoneal 76mg/kg (76mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.
mouse LD50 intravenous 40mg/kg (40mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.
mouse LD50 oral 243mg/kg (243mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.
mouse LD50 subcutaneous 121mg/kg (121mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
rabbit LD50 intravenous 20mg/kg (20mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1439, 1977.
rabbit LD50 oral 525mg/kg (525mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.
rabbit LD50 subcutaneous 164mg/kg (164mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.
rat LD50 intraperitoneal 104mg/kg (104mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.
rat LD50 intravenous 42mg/kg (42mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LIVER: OTHER CHANGES
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1107, 1981.
rat LD50 oral 560mg/kg (560mg/kg)   Drugs in Japan Vol. -, Pg. 766, 1995.
rat LD50 subcutaneous 349mg/kg (349mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1028, 1975.