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Substance Name: Eperisone hydrochloride
RN: 56839-43-1
UNII: U38O8U7P6X
InChIKey: GTAXGNCCEYZRII-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H25-N-O.Cl-H

Molecular Weight

  • 295.851
 
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Names and Synonyms

Results Name

  • Eperisone hydrochloride

Name of Substance

  • (4'-Ethyl-2-methyl-3-piperidino)propiophenone
  • Eperisone hydrochloride
  • Eperisone hydrochloride [JAN]

Synonyms

  • 1-Propanone, 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-, hydrochloride
  • 4'-Ethyl-2-methyl-3-piperidinopropiophenone hydrochloride
  • DW-1030
  • E 0646
  • E-646
  • EMPP
  • Eperisone HCl
  • Eperisone hydrochloride
  • Mional
  • Myonal
  • UNII-U38O8U7P6X

Systematic Names

  • 1-Propanone, 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-, hydrochloride
  • Propiophenone, 4'-ethyl-2-methyl-3-piperidino-, hydrochloride

Registry Numbers

CAS Registry Number

  • 56839-43-1

FDA UNII

  • U38O8U7P6X

System Generated Number

  • 0056839431

Molecular Formulas

Molecular Formula

  • C17-H25-N-O.Cl-H

Molecular Formula Fragments

  • C17-H25-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H25NO.ClH/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18;/h7-10,14H,3-6,11-13H2,1-2H3;1H

InChIKey

GTAXGNCCEYZRII-UHFFFAOYSA-N

Smiles

C([C@@H](CN1CCCCC1)C)(c1ccc(cc1)CC)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 750mg/kg (750mg/kg)   Drugs in Japan Vol. -, Pg. 204, 1990.
mouse LD50 intramuscular 280mg/kg (280mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 939, 1981.
mouse LD50 intraperitoneal 129mg/kg (129mg/kg)   United States Patent Document. Vol. #4528299,
mouse LD50 intravenous 43mg/kg (43mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 939, 1981.
mouse LD50 oral 324mg/kg (324mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 107, Pg. 705, 1987.
mouse LD50 subcutaneous 256mg/kg (256mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 939, 1981.
rat LD50 intramuscular 400mg/kg (400mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 939, 1981.
rat LD50 intravenous 51mg/kg (51mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 939, 1981.
rat LD50 oral 1002mg/kg (1002mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19, Pg. 1743, 1991.
rat LD50 subcutaneous 490mg/kg (490mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 939, 1981.