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Substance Name: Meclozine [INN]
RN: 569-65-3
UNII: 3L5TQ84570
InChIKey: OCJYIGYOJCODJL-UHFFFAOYSA-N

Note

  • A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

Molecular Formula

  • C25-H27-Cl-N2

Molecular Weight

  • 390.9553
 

Classification Codes

  • Anti-Allergic Agents
  • Antiemetics
  • Autonomic Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Human Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Reproductive Effect

Names and Synonyms

Results Name

  • Meclozine [INN]

Name of Substance

  • Meclizine
  • Meclizine [INN:BAN]
  • Meclozine [INN]

MeSH Heading

  • Meclizine

Synonyms

  • (+-)-Meclizine
  • 1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine
  • 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine
  • 1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine
  • 5-23-01-00235 (Beilstein Handbook Reference)
  • Ancolan
  • Bonadettes
  • Bonine
  • BRN 0332002
  • Calmonal
  • Chiclida
  • Dramamine II
  • EINECS 209-323-3
  • Histamethine
  • Histamethizine
  • Histametizine
  • Histametizyne
  • HSDB 3113
  • Itinerol
  • Marex
  • Meclizine
  • Meclozina
  • Meclozina [INN-Spanish]
  • Meclozine
  • Meclozinum
  • Meclozinum [INN-Latin]
  • Monamine
  • Navicalm
  • Neo-istafene
  • Neo-suprimal
  • Neo-suprimel
  • NSC 169189
  • Parachloramine
  • Peremesin
  • Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-
  • Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-
  • Postafene
  • Ravelon
  • Sabari
  • Sea-Legs
  • Siguran
  • Suprimal
  • Travelon
  • U.C.B. 5062
  • UCB 170
  • UCB 5062
  • UNII-3L5TQ84570
  • Vibazine
  • Vomisseis

Systematic Names

  • Meclozine
  • Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-
  • Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-

Registry Numbers

CAS Registry Number

  • 569-65-3

FDA UNII

  • 3L5TQ84570

Related Registry Numbers

  • 1104-22-9 (di-hydrochloride)
  • 36236-67-6 (hydrochloride)

System Generated Number

  • 0000569653

Structure Descriptors

InChI

1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3

InChIKey

OCJYIGYOJCODJL-UHFFFAOYSA-N

Smiles

Cc1cccc(c1)CN2CCN(CC2)C(c3ccccc3)c4ccc(cc4)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 625mg/kg (625mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 oral 1650mg/kg (1650mg/kg)   Compilation of LD50 Values of New Drugs.
rat LD50 oral 1750mg/kg (1750mg/kg)   Proceedings of the European Society for the Study of Drug Toxicity. Vol. 9, Pg. 134, 1968.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Boiling Point 230 deg C   EXP
log P (octanol-water) 5.870 (none)   EST
Atmospheric OH Rate Constant 2.21E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.