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Substance Name: Urea [USP:JAN]
RN: 57-13-6
UNII: 8W8T17847W
InChIKey: XSQUKJJJFZCRTK-UHFFFAOYSA-N

Note

  • A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

Molecular Formula

  • C-H4-N2-O

Molecular Weight

  • 60.0556
 

Classification Codes

  • Diuretic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Names and Synonyms

Name of Substance

  • Carbamide
  • Urea
  • Urea [USP:JAN]

MeSH Heading

  • Urea

Synonyms

  • AI3-01202
  • Alphadrate
  • Antisepsis bolus
  • Aqua Care
  • Aqua Care HP
  • Aquadrate
  • B-I-K
  • Calmurid
  • Carbaderm
  • Carbamide
  • Carbamide resin
  • Carbamimidic acid
  • Carbonyl diamide
  • Carbonyldiamide
  • Carbonyldiamine
  • Caswell No. 902
  • CCRIS 989
  • EC 200-315-5
  • EINECS 200-315-5
  • EPA Pesticide Chemical Code 085702
  • Harnstoff
  • Harnstoff [German]
  • HSDB 163
  • Isourea
  • Keratinamin
  • Mocovina
  • Mocovina [Czech]
  • NCI-C02119
  • NSC 34375
  • Nutraplus
  • Pastaron
  • Prespersion, 75 urea
  • Pseudourea
  • Sterile urea
  • Supercel 3000
  • Ultra Mide
  • UNII-8W8T17847W
  • UR
  • Urea
  • Urea-13C
  • Ureacin-10 lotion
  • Ureacin-20
  • Ureacin-40 Creme
  • Ureaphil
  • Ureophil
  • Urepearl
  • Urevert
  • Varioform II

Systematic Name

  • Urea

Superlist Names

  • Carbamide
  • Urea
  • Urea solution

Mixture Names

  • Aqua Care
  • Cerovel
  • Panafil

Registry Numbers

CAS Registry Number

  • 57-13-6

FDA UNII

  • 8W8T17847W

Other Registry Numbers

  • 118548-06-4
  • 1202865-46-0
  • 1228376-38-2
  • 1637232-71-3
  • 2060607-07-8
  • 30535-50-3
  • 860639-56-1
  • 923953-70-2

System Generated Number

  • 0000057136

Structure Descriptors

InChI

InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

InChIKey

XSQUKJJJFZCRTK-UHFFFAOYSA-N

Smiles

NC(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3gm/kg (3000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
dog LDLo subcutaneous 3gm/kg (3000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
domestic animals - goat/sheep LDLo oral 511mg/kg (511mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TETANY		 American Journal of Physiology. Vol. 153, Pg. 41, 1948.
frog LDLo subcutaneous 600mg/kg (600mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
mouse LD50 intravenous 4600mg/kg (4600mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
mouse LD50 oral 11gm/kg (11000mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(12), Pg. 53, 1987.
mouse LD50 subcutaneous 9200mg/kg (9200mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
mouse LDLo intraperitoneal 6608mg/kg (6608mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Journal of Pharmacology and Experimental Therapeutics. Vol. 57, Pg. 19, 1936.
pigeon LDLo subcutaneous 14800mg/kg (14800mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LDLo intravenous 4800mg/kg (4800mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
rabbit LDLo oral 10gm/kg (10000mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI

BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES		 Japanese Journal of Veterinary Science. Vol. 15, Pg. 125, 1953.
rabbit LDLo subcutaneous 3gm/kg (3000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
rat LD50 intraperitoneal > 5gm/kg (5000mg/kg)   Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. Vol. 257, Pg. 296, 1967.
rat LD50 intratracheal 567mg/kg (567mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(3), Pg. 43, 1986.
rat LD50 intravenous 5300mg/kg (5300mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ANTIPSYCHOTIC		 Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
rat LD50 oral 8471mg/kg (8471mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(6), Pg. 8, 1986.
rat LD50 subcutaneous 8200mg/kg (8200mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 132.7 deg C   EXP
pKa Dissociation Constant 0.1 (none) 21 EXP
log P (octanol-water) -2.11E+00 (none)   EXP
Water Solubility 5.45E+05 mg/L 25 EXP
Henry's Law Constant 1.74E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.00E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.