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Substance Name: Strychnine [BSI:ISO]
RN: 57-24-9
UNII: H9Y79VD43J
InChIKey: QMGVPVSNSZLJIA-FVWCLLPLSA-N

Note

  • An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.

Molecular Formula

  • C21-H22-N2-O2

Molecular Weight

  • 334.4168
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Central Nervous System Agents
  • Central Nervous System Stimulants
  • Convulsants
  • Drug / Therapeutic Agent
  • Glycine Agents
  • Human Data
  • Neurotransmitter Agents
  • Noxae
  • Poisons
  • Reproductive Effect
  • Rodenticide

Superlist Classification Codes

  • Reportable Quantity (RQ) = 10 lb
  • Threshold Planning Quantity (TPQ) = 100/10000 lb
  • TWA 0.15 mg/m3

Names and Synonyms

Results Name

  • Strychnine [BSI:ISO]

Name of Substance

  • Strychnine
  • Strychnine [BSI:ISO]
  • Strychnine [NF]

MeSH Heading

  • Strychnine

Synonyms

  • (-)-Strychnine
  • (4br,7as,8ar,13S,13ar,13bs)-5,6,7a,8,8a,11,13a,13b-octahydro-13H-13,14-ethano-7,9-methanooxepino(3,4-a)pyrrolo(2,3-d)carbazol-15-one
  • Boomer-rid
  • Caswell No. 805
  • Certox
  • Dolco mouse cereal
  • EINECS 200-319-7
  • EPA Pesticide Chemical Code 076901
  • Estricnina
  • Gopher bait
  • Gopher-gitter
  • Hare-Rid
  • HSDB 2001
  • Kwik-kil
  • Mole death
  • Mouse-nots
  • Mouse-rid
  • Mouse-tox
  • NSC 5365
  • Pied piper mouse seed
  • RCRA waste number P108
  • Ro-Dex
  • Sanaseed
  • Stricnina
  • Stricnina [Italian]
  • Strychinos
  • Strychnidin-10-one
  • Strychnin
  • Strychnin [German]
  • Strychnine
  • Strychnos
  • UNII-H9Y79VD43J

Systematic Names

  • Strychnidin-10-one
  • Strychnine

Superlist Names

  • RCRA waste no. P108
  • Strychnidin-10-one
  • Strychnine
  • Strychnine and salts
  • Strychnine or strychnine salts
  • Strychnine or strychnine salts [UN1692] [Poison]
  • UN1692

Registry Numbers

CAS Registry Number

  • 57-24-9

FDA UNII

  • H9Y79VD43J

Other Registry Numbers

  • 101324-33-8
  • 1194719-36-2
  • 525584-40-1
  • 6899-11-2
  • 854644-96-5
  • 875538-26-4
  • 900786-57-4
  • 936009-28-8

System Generated Number

  • 0000057249

Structure Descriptors

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChIKey

QMGVPVSNSZLJIA-FVWCLLPLSA-N

Smiles

c1ccc2c(c1)[C@]34CC[N@@]5[C@H]3C[C@@H]6[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - domestic LDLo oral 2500ug/kg (2.5mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
bird - domestic LDLo subcutaneous 1mg/kg (1mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
bird - wild LD50 oral 16mg/kg (16mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
cat LD50 oral 500ug/kg (0.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
cat LDLo intravenous 330ug/kg (0.33mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
cat LDLo subcutaneous 250ug/kg (0.25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: IRRITABILITY
Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 54, Pg. 234, 1974.
chicken LDLo oral 30mg/kg (30mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
chicken LDLo subcutaneous 3mg/kg (3mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
child TDLo oral 24mg/kg (24mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: GENERAL ANESTHETIC
Pediatric Emergency Care. Vol. 15, Pg. 264, 1999.
dog LD50 intravenous 800ug/kg (0.8mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 126, Pg. 41, 1959.
dog LD50 oral 500ug/kg (0.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
dog LDLo subcutaneous 350ug/kg (0.35mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
duck LD50 oral 3mg/kg (3mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
duck LDLo subcutaneous 1mg/kg (1mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
frog LDLo oral 2100ug/kg (2.1mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
frog LDLo subcutaneous 35ug/kg (0.035mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
guinea pig LDLo subcutaneous 3200ug/kg (3.2mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
human LDLo oral 30mg/kg (30mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1073, 1966.
man LDLo oral 30mg/kg (30mg/kg)   Pesticide Manual. Vol. 9, Pg. 771, 1991.
man LDLo oral 5143mg/kg (5143mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

CARDIAC: CHANGE IN RATE
Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 269, 1992.
man LDLo unreported 1103ug/kg (1.103mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intramuscular 628ug/kg (0.628mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 54, Pg. 234, 1974.
mouse LD50 intraperitoneal 980ug/kg (0.98mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 176, 1960.
mouse LD50 intravenous 410ug/kg (0.41mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 204, 1960.
mouse LD50 oral 2mg/kg (2mg/kg)   Indian Journal of Experimental Biology. Vol. 19, Pg. 1075, 1981.
mouse LD50 parenteral 1060ug/kg (1.06mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 657, 1961.
mouse LD50 subcutaneous 474ug/kg (0.474mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmaceutica Suecica. Vol. 7, Pg. 329, 1970.
mouse LD50 unreported 500ug/kg (0.5mg/kg)   Igaku No Ayumi. Progress in Medicine. Vol. 112, Pg. 861, 1980.
pigeon LD50 oral 21mg/kg (21mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
pigeon LDLo subcutaneous 1mg/kg (1mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
quail LD50 oral 23mg/kg (23mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
rabbit LD50 intravenous 400ug/kg (0.4mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 126, Pg. 41, 1959.
rabbit LDLo oral 600ug/kg (0.6mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
rabbit LDLo subcutaneous 400ug/kg (0.4mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rat LD50 intramuscular 1400ug/kg (1.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 54, Pg. 234, 1974.
rat LD50 intraperitoneal 1100ug/kg (1.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 239, 1936.
rat LD50 intravenous 582ug/kg (0.582mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 54, Pg. 234, 1974.
rat LD50 oral 2350ug/kg (2.35mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 31, Pg. 113, 1942.
rat LD50 subcutaneous 1200ug/kg (1.2mg/kg)   Russian Pharmacology and Toxicology Vol. 31, Pg. 260, 1968.
rat LDLo unreported 1mg/kg (1mg/kg)   Pesticide Manual. Vol. 9, Pg. 771, 1991.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 287 deg C   EXP
pKa Dissociation Constant 8.26 (none) 25 EXP
log P (octanol-water) 1.93 (none)   EXP
Water Solubility 160 mg/L 25 EXP
Vapor Pressure 2.93E-09 mm Hg 25 EST
Henry's Law Constant 7.56E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.21E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.