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Substance Name: Morphine [BAN]
RN: 57-27-2
UNII: 76I7G6D29C
InChIKey: BQJCRHHNABKAKU-KBQPJGBKSA-N
Note
- The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Molecular Formula
- C17-H19-N-O3
Molecular Weight
- 285.3411
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Analgesics
- Analgesics, Opioid
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Narcotics
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
Superlist Classification Code
- DEA Schedule II
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NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Morphine
- Morphine [BAN]
MeSH Heading
- Morphine
Synonyms
- (-)-Morphine
- (5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol
- 4,5alpha-Epoxy-17-methyl-7-morphinen-3,6alpha-diol
- 7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol
- 9H-9,9c-Iminoethanophenanthro(4,5-bcd)furan-3,5-diol, 4a,5,7a,8-tetrahydro-12-methyl-
- Aguettant
- CCRIS 5762
- Cube juice
- DepoDur
- Dimorf
- Dinamorf
- Dreamer
- Dulcontin
- Duramorph
- Duromorph
- EINECS 200-320-2
- Hard stuff
- Hocus
- HSDB 2134
- l-Morphine
- M-Eslon
- Meconium
- Morfina
- Morfina [Italian]
- Morphia
- Morphin
- Morphin [German]
- Morphina
- Morphina [Italian]
- Morphine
- Morphinism
- Morphinum
- Morphium
- Morpho
- Moscontin
- MS Contin
- Ms Emma
- Nepenthe
- Ospalivina
- RMS
- Roxanol
- Sevredol
- Statex SR
- UNII-76I7G6D29C
- Unkie
Systematic Names
- Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-
- Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5alpha,6alpha)-
- Morphine
Superlist Names
- DEA No. 9300
- Morphine
Registry Numbers
CAS Registry Number
- 57-27-2
FDA UNII
- 76I7G6D29C
Other Registry Numbers
- 1325730-46-8
- 47106-99-0
- 8053-16-5
- 85201-37-2
- 863713-90-0
Related Registry Numbers
- 6211-15-0 (sulfate (2:1) (salt) pentahydrate)
- 64-31-3 (sulfate (2:1) (salt) anhydrous)
System Generated Number
- 0000057272
Structure Descriptors
InChI
1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1InChIKey
BQJCRHHNABKAKU-KBQPJGBKSA-NSmiles
CN1CC[C@]23[C@H]4Oc5c(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | subcutaneous | 40mg/kg (40mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
chicken | LDLo | subcutaneous | 900mg/kg (900mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
dog | LD50 | intravenous | 133mg/kg (133mg/kg) | Chemical and Pharmaceutical Bulletin. Vol. 7, Pg. 372, 1959. | |
dog | LDLo | subcutaneous | 210mg/kg (210mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
duck | LDLo | subcutaneous | 900mg/kg (900mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
frog | LDLo | subcutaneous | 600mg/kg (600mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1368, 1935. | |
guinea pig | LDLo | subcutaneous | 500mg/kg (500mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1367, 1935. | |
infant | TDLo | intravenous | 100ug/kg (0.1mg/kg) | CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | American Journal of Hospital Pharmacy. Vol. 51, Pg. 2801, 1994. |
mammal (species unspecified) | LD50 | intraperitoneal | 380mg/kg (380mg/kg) | United States Patent Document. Vol. #4205173, | |
man | LDLo | unreported | 3676ug/kg (3.676mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TDLo | oral | 3857ug/kg/1W- (3.857mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Lancet. Vol. 2, Pg. 98, 1987. |
mouse | LD50 | intracrebral | 6900ug/kg (6.9mg/kg) | Science. Vol. 134, Pg. 1078, 1961. | |
mouse | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 56S, 1957. | |
mouse | LD50 | intravenous | 135mg/kg (135mg/kg) | Therapie. Vol. 7, Pg. 21, 1952. | |
mouse | LD50 | oral | 524mg/kg (524mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974. | |
mouse | LD50 | subcutaneous | 220mg/kg (220mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958. | |
mouse | LD50 | unreported | 500mg/kg (500mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 67(4), Pg. 97P, 1971. | |
pigeon | LDLo | oral | 500mg/kg (500mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1368, 1935. | |
pigeon | LDLo | subcutaneous | 250mg/kg (250mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
rabbit | LDLo | intravenous | 8mg/kg (8mg/kg) | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 3, Pg. 28, 1973. | |
rabbit | LDLo | subcutaneous | 190mg/kg (190mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
rat | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | European Patent Application. Vol. #0047990, | |
rat | LD50 | intravenous | 140mg/kg (140mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 7, Pg. 196, 1952. | |
rat | LD50 | oral | 335mg/kg (335mg/kg) | Drugs of the Future. Vol. 2, Pg. 39, 1977. | |
rat | LD50 | subcutaneous | 109mg/kg (109mg/kg) | Pharmaceutical Chemistry Journal Vol. 23, Pg. 395, 1989. | |
rat | LD50 | unreported | 134mg/kg (134mg/kg) | Farmakologiya i Toksikologiya Vol. 39, Pg. 14, 1976. | |
women | TDLo | intramuscular | 152ug/kg (0.152mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | International Journal of Clinical Pharmacology, Therapy and Toxicology. Vol. 30, Pg. 202, 1992. |
women | TDLo | intravenous | 1458ug/kg/C (1.458mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SLEEP | British Medical Journal. Vol. 309, Pg. 1002, 1994. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 255 | deg C | EXP | |
pKa Dissociation Constant | 8.21 | (none) | 25 | EXP |
log P (octanol-water) | 0.89 | (none) | EXP | |
Water Solubility | 149 | mg/L | 20 | EXP |
Vapor Pressure | 1.69E-09 | mm Hg | 25 | EST |
Henry's Law Constant | 1.33E-16 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.05E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.