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Substance Name: Pentobarbital sodium [USP:JAN]
RN: 57-33-0
UNII: NJJ0475N0S
InChIKey: QGMRQYFBGABWDR-UHFFFAOYSA-M

Molecular Formula

  • C11-H18-N2-O3.Na

Molecular Weight

  • 248.256
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Sedative-Hypnotic

Superlist Classification Code

  • DEA Schedule II

Names and Synonyms

Name of Substance

  • Pentobarbital sodium [USP:JAN]

MeSH Heading

  • Pentobarbital

Synonyms

  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-, monosodium salt
  • 5-Ethyl-5-(1-methylbutyl) barbituric acid sodium salt
  • 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione monosodium salt
  • 5-Ethyl-5-(1-methylbutyl)barbituric acid sodium salt
  • Auropan
  • Barbituric acid, 5-ethyl-5-sec-pentyl-, sodium salt
  • Barpental
  • Biosedan
  • Butylmethyl ethyl malonyl urea sodium
  • Butylone [Barbiturate]
  • Continal
  • Diabutal
  • EINECS 200-323-9
  • Embutal
  • Etaminal sodium
  • Ethaminal sodium
  • Eutha 77
  • Euthanyl
  • Euthatal
  • Isobarb
  • Lethobarb
  • Mebubarbital sodium
  • Mebumal sodium
  • Mebunat
  • Mintal
  • Napental
  • Nembutal
  • Nembutal sodium
  • NSC 10816
  • Pacifan
  • Palapent
  • Penbar
  • Pentabarbital sodium
  • Pental
  • Pentobarbital sodium
  • Pentobarbitone sodium
  • Pentonal
  • Pentone
  • Pentosol
  • Propylmethylcarbinylethyl barbituric acid sodium salt
  • Rivadorn
  • RS-Pentobarbital sodium
  • Sagatal
  • Sodium 5-ethyl-5-(1-methylbutyl)barbiturate
  • Sodium ethaminal
  • Sodium nembutal
  • Sodium pentobarbital
  • Sodium pentobarbitone
  • Sodium pentobarbiturate
  • Sodium-Pent
  • Soluble pentobarbital
  • Somnopentyl
  • Sonistan
  • Sontobarbital nabitone
  • Sopental
  • Sotyl
  • UNII-NJJ0475N0S
  • V-Pento
  • Vetbutal

Systematic Names

  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-, monosodium salt
  • Barbituric acid, 5-ethyl-5-(1-methylbutyl)-, sodium salt
  • Pentobarbital sodium

Superlist Names

  • DEA No. 2270
  • Nembutal
  • Pentobarbital sodium

Mixture Names

  • Carbrital
  • Sedalixir

Registry Numbers

CAS Registry Number

  • 57-33-0

FDA UNII

  • NJJ0475N0S

Other Registry Numbers

  • 10579-81-4
  • 23714-57-0
  • 8023-11-8
  • 8050-99-5

Related Registry Number

  • 76-74-4 (Parent)

System Generated Number

  • 0000057330

Molecular Formulas

Molecular Formula

  • C11-H18-N2-O3.Na

Molecular Formula Fragments

  • C11-H18-N2-O3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C11H18N2O3.Na/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1

InChIKey

QGMRQYFBGABWDR-UHFFFAOYSA-M

Smiles

C1([C@@](C(N=C(N1)[O-])=O)([C@@H](CCC)C)CC)=O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 75mg/kg (75mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat LD50 oral 100mg/kg (100mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 260, 1946.
cat LDLo intraperitoneal 70mg/kg (70mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 46, Pg. 387, 1932.
chicken LD50 intraperitoneal 51540ug/kg (51.54mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960.
chicken LD50 intravenous 48mg/kg (48mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960.
dog LD50 oral 65mg/kg (65mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 119, 1944.
dog LDLo intraperitoneal 50mg/kg (50mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 181, 1973.
dog LDLo intravenous 50mg/kg (50mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 125, 1937.
duck LD50 oral 75mg/kg (75mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
guinea pig LD50 intramuscular 70300ug/kg (70.3mg/kg) BEHAVIORAL: SLEEP Canadian Anaesthetists' Society Journal. Vol. 2, Pg. 109, 1955.
guinea pig LD50 oral 60mg/kg (60mg/kg)   Compilation of LD50 Values of New Drugs.
guinea pig LD50 subcutaneous 70mg/kg (70mg/kg) AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962.
guinea pig LDLo intraperitoneal 56mg/kg (56mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 33, Pg. 527, 1936.
man TDLo oral 6430ug/kg (6.43mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ANTIPSYCHOTIC
Journal of Pharmacology and Experimental Therapeutics. Vol. 197, Pg. 488, 1976.
mouse LD50 intracrebral 6500ug/kg (6.5mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 197, Pg. 479, 1976.
mouse LD50 intramuscular 124mg/kg (124mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 138, 1951.
mouse LD50 intraperitoneal 126mg/kg (126mg/kg)   Journal of Medicinal Chemistry. Vol. 12, Pg. 989, 1969.
mouse LD50 intravenous 81mg/kg (81mg/kg)   European Journal of Pharmacology. Vol. 13, Pg. 150, 1971.
mouse LD50 oral 239mg/kg (239mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 2180, 1981.
mouse LD50 subcutaneous 122mg/kg (122mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
pigeon LD50 oral 133mg/kg (133mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rabbit LD50 intraperitoneal 65mg/kg (65mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 253, 1931.
rabbit LD50 intravenous 40mg/kg (40mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 44, Pg. 221, 1955.
rabbit LD50 oral 175mg/kg (175mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 253, 1931.
rabbit LDLo parenteral 60mg/kg (60mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 465, 1931.
rabbit LDLo rectal 65mg/kg (65mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 189, 1937.
rat LD50 intraduodenal 39mg/kg (39mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat LD50 intraperitoneal 36mg/kg (36mg/kg)   Food and Cosmetics Toxicology. Vol. 3, Pg. 597, 1965.
rat LD50 intravenous 65mg/kg (65mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 135, Pg. 213, 1962.
rat LD50 oral 118mg/kg (118mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rat LD50 subcutaneous 47mg/kg (47mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat LDLo intravenous 80mg/kg (80mg/kg)   Journal of the American Chemical Society. Vol. 56, Pg. 1772, 1934.
women TDLo oral 60mg/kg (60mg/kg) BEHAVIORAL: WAKEFULNESS Journal of Laboratory and Clinical Medicine. Vol. 29, Pg. 265, 1944.