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Substance Name: Benactyzine hydrochloride
RN: 57-37-4
UNII: 26R628272Q
InChIKey: ZCEHOOLYWQBGQO-UHFFFAOYSA-N

Note

  • A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.

Molecular Formula

  • C20-H25-N-O3.Cl-H

Molecular Weight

  • 363.8824
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Benactyzine hydrochloride

Name of Substance

  • Benactyzine hydrochloride

Synonyms

  • 2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid
  • 2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [Czech]
  • 2-Diethylaminoethyl benzilate hydrochloride
  • 2-Diethylaminoethyl diphenylglycolate hydrochloride
  • 2-Diethylaminoethylester kyseliny benzilove hydrochlorid
  • 2-Diethylaminoethylester kyseliny benzilove hydrochlorid [Czech]
  • AI3-26379
  • Aktozin
  • Amisil
  • Amisyl
  • Amitakon
  • Amizil
  • Amizil hydrochloride
  • Amizyl hydrochloride
  • Amysyl
  • Amyzyl
  • Arkadin
  • AY 5406-1
  • Benactizine hydrochloride
  • Benactyzin
  • Benactyzin [Czech]
  • Benactyzine chloride
  • Benactyzine HCl
  • Benactyzine hydrochloride
  • Benaktin
  • Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride
  • Benzilate du diethylamino-ethanol chlorhydrate
  • Benzilate du diethylamino-ethanol chlorhydrate [French]
  • Benzilic acid beta-diethylaminoethyl ester hydrochloride
  • beta-Diethylaminoethyl benzilate hydrochloride
  • Cafron
  • Cedad
  • Cevanol
  • Deprol
  • Destendo
  • Diphenylglycollic acid 2-(diethylamino)ethyl ester hydrochloride
  • EA 2092
  • EINECS 200-324-4
  • Ethanol, 2-(diethylamino)-, benzilate hydrochloride
  • Fobex
  • Ibiotyzil
  • Katron
  • Leucidil
  • Lucidil
  • Morcain
  • Nervacton
  • Nervatil
  • Neuraktil
  • Neurobenzil
  • Neuroleptone
  • NSC 16339
  • Nutinal
  • Parasan
  • Parazan
  • Parpon
  • Phobex
  • Procalm
  • Prokalm
  • Stoikon
  • Suavitil
  • Tranquillin
  • Tranquilline
  • UNII-26R628272Q
  • Valladan
  • Valladon
  • WIN 5606

Systematic Names

  • Benactyzine hydrochloride
  • Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride
  • Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
  • Benzilic acid, 2-(diethylamino)ethyl ester, hydrochloride

Registry Numbers

CAS Registry Number

  • 57-37-4

FDA UNII

  • 26R628272Q

Other Registry Number

  • 2702-56-9

System Generated Number

  • 0000057374

Molecular Formulas

Molecular Formula

  • C20-H25-N-O3.Cl-H

Molecular Formula Fragments

  • C20-H25-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H25NO3.ClH/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,23H,3-4,15-16H2,1-2H3;1H

InChIKey

ZCEHOOLYWQBGQO-UHFFFAOYSA-N

Smiles

Cl.C(c1ccccc1)(c1ccccc1)(C(=O)OCCN(CC)CC)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Acta Pharmacologica et Toxicologica. Vol. 11, Pg. 405, 1955.
human TDLo oral 14ug/kg (0.014mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 363, 1972.
mouse LD50 intradermal 350mg/kg (350mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 59, Pg. 149, 1938.
mouse LD50 intraperitoneal 76mg/kg (76mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 274, 1942.
mouse LD50 intravenous 14300ug/kg (14.3mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 673, 1986.
mouse LD50 oral 160mg/kg (160mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 363, 1972.
mouse LD50 subcutaneous 250mg/kg (250mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 363, 1972.
rabbit LD50 intraperitoneal 100mg/kg (100mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT
Acta Pharmacologica et Toxicologica. Vol. 11, Pg. 405, 1955.
rabbit LD50 intravenous 15mg/kg (15mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 363, 1972.
rat LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Acta Pharmacologica et Toxicologica. Vol. 11, Pg. 405, 1955.
rat LD50 oral 184mg/kg (184mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 42, 1959.