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Substance Name: Propylene glycol [USP:JAN]
RN: 57-55-6
UNII: 6DC9Q167V3
InChIKey: DNIAPMSPPWPWGF-UHFFFAOYSA-N

Note

  • A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.

Molecular Formula

  • C3-H8-O2

Molecular Weight

  • 76.0942
 

Classification Codes

  • Agricultural Chemical
  • Germicide, Bactericide, Disinfectant
  • Human Data
  • Mutation Data
  • Pharmaceutic Aid (Humectant)
  • Pharmaceutic Aid (Solvent)
  • Pharmaceutic Aid (Suspending Agent)
  • Pharmaceutic Aids
  • Pharmaceutical Vehicles
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents

Names and Synonyms

Name of Substance

  • 1,2-Propanediol
  • Propylene glycol
  • Propylene glycol [USP:JAN]

MeSH Heading

  • Propylene glycol

Synonyms

  • (+-)-1,2-Propanediol
  • (+-)-Propylene glycol
  • (RS)-1,2-Propanediol
  • 1,2-Dihydroxypropane
  • 1,2-Propylene glycol
  • 1,2-Propylenglykol
  • 1,2-Propylenglykol [German]
  • 2,3-Propanediol
  • 2-Hydroxypropanol
  • 3-01-00-02142 (Beilstein Handbook Reference)
  • AI3-01898
  • All purpose lubricant
  • alpha-Propyleneglycol
  • BRN 1340498
  • Caswell No. 713
  • CCRIS 5929
  • DL-1,2-Propanediol
  • dl-Propylene glycol
  • Dowfrost
  • EC 200-338-0
  • EINECS 200-338-0
  • EPA Pesticide Chemical Code 068603
  • FEMA No. 2940
  • General lube
  • HSDB 174
  • Isopropylene glycol
  • Methylethyl glycol
  • Methylethylene glycol
  • Monopropylene glycol
  • NSC 69860
  • PG 12
  • Propane-1,2-diol
  • Propylene glycol
  • Propylene Glycol USP
  • Sentry Propylene Glycol
  • Sirlene
  • Solar Winter BAN
  • Solargard P
  • Trimethyl glycol
  • Ucar 35
  • UNII-6DC9Q167V3

Systematic Names

  • 1,2-Propanediol
  • 1,2-Propylene glycol
  • Propane-1,2-diol

Superlist Names

  • 1,2-Propanediol
  • 1,2-Propylene glycol
  • Propylene glycol

Mixture Name

  • SDM No. 27

Registry Numbers

CAS Registry Number

  • 57-55-6

FDA UNII

  • 6DC9Q167V3

Other Registry Numbers

  • 1194046-20-2
  • 190913-75-8
  • 4254-16-4
  • 63625-56-9

Related Registry Number

  • 58858-91-6 (hydrochloride salt)

System Generated Number

  • 0000057556

Structure Descriptors

InChI

InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

InChIKey

DNIAPMSPPWPWGF-UHFFFAOYSA-N

Smiles

CC(O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intravenous 27gm/kg (27000mg/kg) VASCULAR: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 312, 1937.
child TDLo oral 79gm/kg/56W-I (79000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BRAIN AND COVERINGS: CHANGES IN SURFACE EEG

BEHAVIORAL: GENERAL ANESTHETIC		 Journal of Pediatrics. Vol. 93, Pg. 515, 1978.
dog LD50 intravenous 26gm/kg (26000mg/kg)   National Technical Information Service. Vol. PB280-477,
dog LD50 oral 22gm/kg (22000mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
guinea pig LD50 oral 18350mg/kg (18350mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig LDLo subcutaneous 15500mg/kg (15500mg/kg)   National Technical Information Service. Vol. PB280-477,
infant TDLo parenteral 10gm/kg/3D-C (10000mg/kg)   Pediatrics. Vol. 72, Pg. 353, 1983.
mouse LD50 intraperitoneal 9718mg/kg (9718mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: CHANGES IN SPLEEN

KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI		 Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse LD50 intravenous 6630mg/kg (6630mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 oral 22gm/kg (22000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.
mouse LD50 subcutaneous 17370mg/kg (17370mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 8, Pg. 46, 1981.
quail LD50 oral > 2080mg/kg (2080mg/kg)   Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
rabbit LD50 intravenous 6500mg/kg (6500mg/kg)   National Technical Information Service. Vol. PB280-477,
rabbit LD50 oral 18500mg/kg (18500mg/kg)   FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 491, 1974.
rabbit LD50 skin 20800mg/kg (20800mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 101, 1974.
rabbit LDLo intramuscular 6300mg/kg (6300mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 109, 1932.
rat LD50 intramuscular 14gm/kg (14000mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
rat LD50 intraperitoneal 6660mg/kg (6660mg/kg)   Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981.
rat LD50 intravenous 6423mg/kg (6423mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 oral 20gm/kg (20000mg/kg)   Toxicology and Applied Pharmacology. Vol. 45, Pg. 362, 1978.
rat LD50 subcutaneous 22500mg/kg (22500mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -6.00E+01 deg C   EXP
Boiling Point 187.6 deg C   EXP
pKa Dissociation Constant 14.9 (none)   EXP
log P (octanol-water) -0.92 (none)   EXP
Water Solubility 1.00E+06 mg/L 20 EXP
Vapor Pressure 0.129 mm Hg 25 EXP
Henry's Law Constant 1.29E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.20E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.