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Substance Name: Propylene glycol [USP:JAN]
RN: 57-55-6
UNII: 6DC9Q167V3
InChIKey: DNIAPMSPPWPWGF-UHFFFAOYSA-N
Note
- A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
Molecular Formula
- C3-H8-O2
Molecular Weight
- 76.0942
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Agricultural Chemical
- Germicide, Bactericide, Disinfectant
- Human Data
- Mutation Data
- Pharmaceutic Aid (Humectant)
- Pharmaceutic Aid (Solvent)
- Pharmaceutic Aid (Suspending Agent)
- Pharmaceutic Aids
- Pharmaceutical Vehicles
- Reproductive Effect
- Skin / Eye Irritant
- Solvents
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Regulatory Agencies (Superlist Locators)
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Names and Synonyms
Name of Substance
- 1,2-Propanediol
- Propylene glycol
- Propylene glycol [USP:JAN]
MeSH Heading
- Propylene glycol
Synonyms
- (+-)-1,2-Propanediol
- (+-)-Propylene glycol
- (RS)-1,2-Propanediol
- 1,2-Dihydroxypropane
- 1,2-Propylene glycol
- 1,2-Propylenglykol
- 1,2-Propylenglykol [German]
- 2,3-Propanediol
- 2-Hydroxypropanol
- 3-01-00-02142 (Beilstein Handbook Reference)
- AI3-01898
- All purpose lubricant
- alpha-Propyleneglycol
- BRN 1340498
- Caswell No. 713
- CCRIS 5929
- DL-1,2-Propanediol
- dl-Propylene glycol
- Dowfrost
- EC 200-338-0
- EINECS 200-338-0
- EPA Pesticide Chemical Code 068603
- FEMA No. 2940
- General lube
- HSDB 174
- Isopropylene glycol
- Methylethyl glycol
- Methylethylene glycol
- Monopropylene glycol
- NSC 69860
- PG 12
- Propane-1,2-diol
- Propylene glycol
- Propylene Glycol USP
- Sentry Propylene Glycol
- Sirlene
- Solar Winter BAN
- Solargard P
- Trimethyl glycol
- Ucar 35
- UNII-6DC9Q167V3
Systematic Names
- 1,2-Propanediol
- 1,2-Propylene glycol
- Propane-1,2-diol
Superlist Names
- 1,2-Propanediol
- 1,2-Propylene glycol
- Propylene glycol
Mixture Name
- SDM No. 27
Registry Numbers
CAS Registry Number
- 57-55-6
FDA UNII
- 6DC9Q167V3
Other Registry Numbers
- 1194046-20-2
- 190913-75-8
- 4254-16-4
- 63625-56-9
Related Registry Number
- 58858-91-6 (hydrochloride salt)
System Generated Number
- 0000057556
Structure Descriptors
InChI
1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3InChIKey
DNIAPMSPPWPWGF-UHFFFAOYSA-NSmiles
C([C@@H](C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LDLo | intravenous | 27gm/kg (27000mg/kg) | VASCULAR: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 312, 1937. |
child | TDLo | oral | 79gm/kg/56W-I (79000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: GENERAL ANESTHETIC | Journal of Pediatrics. Vol. 93, Pg. 515, 1978. |
dog | LD50 | intravenous | 26gm/kg (26000mg/kg) | National Technical Information Service. Vol. PB280-477, | |
dog | LD50 | oral | 22gm/kg (22000mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939. | |
guinea pig | LD50 | oral | 18350mg/kg (18350mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. | |
guinea pig | LDLo | subcutaneous | 15500mg/kg (15500mg/kg) | National Technical Information Service. Vol. PB280-477, | |
infant | TDLo | parenteral | 10gm/kg/3D-C (10000mg/kg) | Pediatrics. Vol. 72, Pg. 353, 1983. | |
mouse | LD50 | intraperitoneal | 9718mg/kg (9718mg/kg) | LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: CHANGES IN SPLEEN KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947. |
mouse | LD50 | intravenous | 6630mg/kg (6630mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976. | |
mouse | LD50 | oral | 22gm/kg (22000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939. | |
mouse | LD50 | subcutaneous | 17370mg/kg (17370mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 8, Pg. 46, 1981. |
quail | LD50 | oral | > 2080mg/kg (2080mg/kg) | Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. | |
rabbit | LD50 | intravenous | 6500mg/kg (6500mg/kg) | National Technical Information Service. Vol. PB280-477, | |
rabbit | LD50 | oral | 18500mg/kg (18500mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 491, 1974. | |
rabbit | LD50 | skin | 20800mg/kg (20800mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 101, 1974. | |
rabbit | LDLo | intramuscular | 6300mg/kg (6300mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 109, 1932. |
rat | LD50 | intramuscular | 14gm/kg (14000mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
rat | LD50 | intraperitoneal | 6660mg/kg (6660mg/kg) | Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981. | |
rat | LD50 | intravenous | 6423mg/kg (6423mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976. | |
rat | LD50 | oral | 20gm/kg (20000mg/kg) | Toxicology and Applied Pharmacology. Vol. 45, Pg. 362, 1978. | |
rat | LD50 | subcutaneous | 22500mg/kg (22500mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -6.00E+01 | deg C | EXP | |
Boiling Point | 187.6 | deg C | EXP | |
pKa Dissociation Constant | 14.9 | (none) | EXP | |
log P (octanol-water) | -0.92 | (none) | EXP | |
Water Solubility | 1.00E+06 | mg/L | 20 | EXP |
Vapor Pressure | 0.129 | mm Hg | 25 | EXP |
Henry's Law Constant | 1.29E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.20E-11 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.