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Substance Name: Propiolactone [USAN:INN:BAN]
RN: 57-57-8
UNII: 6RC3ZT4HB0
InChIKey: VEZXCJBBBCKRPI-UHFFFAOYSA-N
Note
- Disinfectant used in vapor form to sterilize vaccines, grafts, etc. The vapor is very irritating and the liquid form is carcinogenic.
Molecular Formula
- C3-H4-O2
Molecular Weight
- 72.0626
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Agricultural Chemical
- Anti-Infective Agents
- Disinfectant
- Disinfectants
- Germicide, Bactericide, Disinfectant
- Mutation Data
- Tumor Data
Superlist Classification Codes
- Overall Carcinogenic Evaluation: Group 2B
- Reasonably Anticipated to be a Carcinogen
- Reportable Quantity (RQ) = 10 lb
- Threshold Planning Quantity (TPQ) = 500 lb
- TWA (0.5 ppm); Confirmed animal carcinogen with unknown relevance to humans
- TWA see 1910.1013
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Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- beta-Propiolactone
- Propiolactone [USAN:INN:BAN]
MeSH Heading
- Propiolactone
Synonyms
- 1,3-Propiolactone
- 2-Oxetanone
- 3-Hydroxypropionic acid lactone
- 3-Propanolide
- 3-Propiolactone
- 5-17-09-00003 (Beilstein Handbook Reference)
- AI3-24257
- beta-Propanoic acid lactone
- beta-Propiolactone
- beta-Propiolakton
- beta-Propiolakton [Czech]
- beta-Propionolactone
- beta-Proprolactone
- Betaprone
- BPL
- BRN 0001360
- Caswell No. 709
- CCRIS 536
- EC 200-340-1
- EINECS 200-340-1
- EPA Pesticide Chemical Code 010901
- HSDB 811
- Hydracrylic acid beta-lactone
- NSC 21626
- Propanoic acid, 3-hydroxy-, beta-lactone
- Propanolide
- Propiolactona
- Propiolactona [INN-Spanish]
- Propiolactone
- Propiolactonum
- Propiolactonum [INN-Latin]
- Propiolattone
- Propiolattone [DCIT]
- Propionic acid, 3-hydroxy-, beta-lactone
- UNII-6RC3ZT4HB0
Systematic Names
- 2-Oxetanone
- Propiolactone
Superlist Names
- 2-Oxetanone
- beta-Propiolactone
- Propiolactone, beta-
Registry Numbers
CAS Registry Number
- 57-57-8
FDA UNII
- 6RC3ZT4HB0
System Generated Number
- 0000057578
Structure Descriptors
InChI
1S/C3H4O2/c4-3-1-2-5-3/h1-2H2InChIKey
VEZXCJBBBCKRPI-UHFFFAOYSA-NSmiles
C1(CCO1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 405mg/kg (405mg/kg) | JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979. | |
| rat | LC50 | inhalation | 25ppm/6H (25ppm) | "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 497, 1986. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | -3.34E+01 | deg C | EXP | |
| Boiling Point | 162 | deg C | EXP | |
| log P (octanol-water) | -0.800 | (none) | EST | |
| Water Solubility | 3.70E+05 | mg/L | 25 | EXP |
| Vapor Pressure | 3.400 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.28E-05 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 6.14E-13 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.