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Substance Name: Physostigmine salicylate [USP:JAN]
RN: 57-64-7
UNII: 2046ZRO9VU
InChIKey: HZOTZTANVBDFOF-PBCQUBLHSA-N
Note
- A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Molecular Formula
- C15-H21-N3-O2.C7-H6-O3
Molecular Weight
- 413.4713
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Cholinergic (Ophthalmic)
- Drug / Therapeutic Agent
- Human Data
- Reproductive Effect
Superlist Classification Code
- Threshold Planning Quantity (TPQ) = 100/10000 lb
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Names and Synonyms
Name of Substance
- Physostigmine salicylate
- Physostigmine salicylate [USP:JAN]
Synonyms
- Antilirium
- AR-44
- CCRIS 3405
- EINECS 200-343-8
- Eserine salicylate
- Isopto Eserine
- NSC 757275
- Physostigmine monosalicylate
- Physostigmine salicylate
- Physostol salicylate
- Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, mono(2-hydroxybenzoate)
- Salicylic acid, compd. with physostigmine (1:1)
- TL-1380
- UNII-2046ZRO9VU
Systematic Names
- Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl methylcarbamate (1:1)
- Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl N-methylcarbamate (1:1)
- Physostigmine salicylate
- Physostigmine, salicylate (1:1)
- Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, mono(2-hydroxybenzoate)
Superlist Names
- Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl methylcarbamate ester (1:1)
- Physostigmine salicylate
- Physostigmine, salicylate (1:1)
- RCRA waste no. P188
Mixture Name
- Isopto P-ES
Registry Numbers
CAS Registry Number
- 57-64-7
FDA UNII
- 2046ZRO9VU
Other Registry Numbers
- 11033-04-8
- 11036-66-1
System Generated Number
- 0000057647
Molecular Formulas
Molecular Formula
- C15-H21-N3-O2.C7-H6-O3
Molecular Formula Fragments
- C15-H21-N3-O2
- C7-H6-O3
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/m1./s1InChIKey
HZOTZTANVBDFOF-PBCQUBLHSA-NSmiles
CNC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | subcutaneous | 800ug/kg (0.8mg/kg) | BEHAVIORAL: COMA AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | National Technical Information Service. Vol. PB158-508, |
dog | LDLo | subcutaneous | 1200ug/kg (1.2mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | National Technical Information Service. Vol. PB158-508, |
man | TDLo | intravenous | 14ug/kg (0.014mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Clinical Psychiatry. Vol. 46, Pg. 446, 1985. |
mouse | LD50 | intraperitoneal | 640ug/kg (0.64mg/kg) | Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974. | |
mouse | LD50 | intravenous | 310ug/kg (0.31mg/kg) | Toxicology and Applied Pharmacology. Vol. 20, Pg. 474, 1971. | |
mouse | LD50 | oral | 2500ug/kg (2.5mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 81, Pg. 276, 1950. |
mouse | LD50 | subcutaneous | 800ug/kg (0.8mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Journal of Pharmacy and Pharmacology. Vol. 34, Pg. 603, 1982. |
rabbit | LD50 | intramuscular | 1570ug/kg (1.57mg/kg) | BEHAVIORAL: TREMOR | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 81, Pg. 276, 1950. |
rabbit | LD50 | intravenous | 910ug/kg (0.91mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Toxicology and Applied Pharmacology. Vol. 165, Pg. 27, 2000. |
rabbit | LDLo | subcutaneous | 2mg/kg (2mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 53, Pg. 313, 1905. | |
rat | LD50 | intramuscular | 1280ug/kg (1.28mg/kg) | Drug and Chemical Toxicology. Vol. 7, Pg. 507, 1984. | |
rat | LD50 | subcutaneous | 2mg/kg (2mg/kg) | Toxicology and Applied Pharmacology. Vol. 25, Pg. 569, 1973. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 150.1 | deg C | EXP | |
log P (octanol-water) | 2.380 | (none) | EST | |
Water Solubility | 1.38E+04 | mg/L | 25 | EXP |
Vapor Pressure | 3.10E-16 | mm Hg | 25 | EST |
Henry's Law Constant | 3.36E-22 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.58E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.