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Substance Name: Progesterone [USP:INN:BAN:JAN]
RN: 57-83-0
UNII: 4G7DS2Q64Y
InChIKey: RJKFOVLPORLFTN-LEKSSAKUSA-N

Note

  • The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

Molecular Formula

  • C21-H30-O2

Molecular Weight

  • 314.466
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Mutation Data
  • Progestin
  • Progestins
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Reasonably Anticipated to be a Carcinogen

Names and Synonyms

Name of Substance

  • Progesterone
  • Progesterone [USP:INN:BAN:JAN]

MeSH Heading

  • Progesterone

Synonyms

  • 17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione
  • 17alpha-Progesterone
  • 3,20-Pregnene-4
  • 4-Pregnene-3,20-dione
  • 6alpha-Methylpregn-4-en-17alpha-ol-3,20-dione
  • Agolutin
  • AI3-51682
  • Bio-luton
  • CCRIS 533
  • Corlutin
  • Corlutina
  • Corluvite
  • Corporin
  • Corpus luteum hormone
  • Crinone
  • Crinone progesterone gel
  • Cyclogest
  • delta(sup 4)-Pregnene-3,20-dione
  • EC 200-350-6
  • EINECS 200-350-6
  • Endometrin
  • Flavolutan
  • Fologenon
  • Gesterol
  • Gesterol 100
  • Gesterol 50
  • Gestone
  • Gestormone
  • Gestron
  • Glanducorpin
  • Gynlutin
  • Gynoluton
  • Gynolutone
  • Hormoflaveine
  • Hormoluton
  • HSDB 3389
  • Lingusorbs
  • Lipo-Lutin
  • Lucorteum
  • Lucorteum Sol
  • Luteal hormone
  • Luteinique
  • Luteocrin normale
  • Luteodyn
  • Luteogan
  • Luteohormone
  • Luteol
  • Luteol (VAN)
  • Luteopur
  • Luteosan
  • Luteostab
  • Luteovis
  • Lutex
  • Lutidon
  • Lutin
  • Lutociclina
  • Lutocyclin
  • Lutocyclin M
  • Lutocylin
  • Lutoform
  • Lutogyl
  • Lutren
  • Lutromone
  • Membrettes
  • Methylpregnone
  • Nalutron
  • NSC 64377
  • NSC 9704
  • NSC-9704
  • Percutacrine Luteinique
  • Piaponon
  • Pregn-4-ene-3,20-dione, 17alpha-hydroxy-6alpha-methyl-
  • Pregnene-3,20-dione
  • Pregnenedione
  • Primolut
  • Prochieve
  • Progekan
  • Progestasert
  • Progesterol
  • Progesterona
  • Progesterona [INN-Spanish]
  • Progesterone
  • Progesteronum
  • Progesteronum [INN-Latin]
  • Progestin
  • Progestone
  • Progestosol
  • Progestron
  • Progestronol
  • Projestaject
  • Prolets
  • Prolidon
  • Proluton
  • Prolutone
  • Prometrium
  • Protormone
  • Syngesterone
  • Syngestrets
  • Synovex S
  • Syntolutan
  • UNII-4G7DS2Q64Y
  • Utrogestan

Systematic Names

  • Pregn-4-ene-3,20-dione
  • Progesterone

Superlist Names

  • Pregn-4-ene-3,20-dione
  • Progesterone
  • Progesterone [Progestins]

Mixture Name

  • Cyclogesterin

Registry Numbers

CAS Registry Number

  • 57-83-0

FDA UNII

  • 4G7DS2Q64Y

Other Registry Numbers

  • 2051138-40-8
  • 257630-50-5
  • 753497-20-0
  • 8012-32-6
  • 8023-13-0

System Generated Number

  • 0000057830

Structure Descriptors

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChIKey

RJKFOVLPORLFTN-LEKSSAKUSA-N

Smiles

C1[C@H]2[C@H]([C@H]3[C@@]([C@@H](C(C)=O)CC3)(C)C1)CCC=1[C@@]2(CCC(C1)=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intravenous 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968.
rat LD50 intraperitoneal 327mg/kg (327mg/kg)   Drugs in Japan Vol. -, Pg. 1183, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 121 deg C   EXP
log P (octanol-water) 3.87 (none)   EXP
Water Solubility 8.81 mg/L 25 EXP
Vapor Pressure 1.30E-06 mm Hg 25 EST
Henry's Law Constant 6.49E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.04E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.