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Substance Name: Alfatradiol [INN]
RN: 57-91-0
UNII: 3VQ38D63M7
InChIKey: VOXZDWNPVJITMN-SFFUCWETSA-N
Notes
- /Estradiol/ Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors ( RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.
- Used for treating androgenetic alopecia.
Molecular Formula
- C18-H24-O2
Molecular Weight
- 272.3856
- All
- Classifications
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- Registry Numbers
- Structure Descriptors
- Physical Properties
Classification Codes
- 5-alpha Reductase Inhibitors
- Dermatologic Agents
- Enzyme Inhibitors
- Hormone
- Hormone Antagonists
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Mutation Data
- Steroid Synthesis Inhibitors
- Tumor Data
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Names and Synonyms
Name of Substance
- Alfatradiol [INN]
Synonyms
- 1,3,5-Estratriene-3,17-alpha-diol
- 17alpha-Estradiol
- 3,17-alpha-Dihydroxyoestra-1,3,5(10)-triene
- 3,17-Dihydroxyestratriene
- 3,17alpha-Dihydroxyestra-1,3,5(10)-triene
- 3,17alpha-Dihydroxyoestra-1,3,5(10)-triene
- 4-06-00-06611 (Beilstein Handbook Reference)
- Alfatradiol
- alpha-Estradiol
- BRN 2698044
- CCRIS 7203
- EINECS 200-354-8
- Epiestradiol
- Estra-1,3,5(10)-triene-3,17alpha-diol
- NSC 20293
- Oestra-1,3,5(10)-triene-3,17alpha-diol
- Oestradiol-17-alpha
- Oestradiol-17alpha
- UNII-3VQ38D63M7
Systematic Names
- 17-alpha-Estradiol
- 17alpha-Estradiol
- Estra-1,3,5(10)-triene-3,17-diol, (17-alpha)-
- Estra-1,3,5(10)-triene-3,17alpha-diol
Registry Numbers
CAS Registry Number
- 57-91-0
FDA UNII
- 3VQ38D63M7
System Generated Number
- 0000057910
Structure Descriptors
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1InChIKey
VOXZDWNPVJITMN-SFFUCWETSA-NSmiles
C[C@]12CC[C@H]3[C@@H](CCc4cc(O)Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 221.5 | deg C | EXP | |
log P (octanol-water) | 3.940 | (none) | EST | |
Water Solubility | 3.9 | mg/L | 25 | EXP |
Atmospheric OH Rate Constant | 1.23E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.