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Substance Name: Streptomycin [INN:BAN]
RN: 57-92-1
UNII: Y45QSO73OB
InChIKey: UCSJYZPVAKXKNQ-HZYVHMACSA-N
Note
- An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Molecular Formula
- C21-H39-N7-O12
Molecular Weight
- 581.5761
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Agricultural Chemical
- Anti-Bacterial Agents
- Anti-Infective Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Fungicide, Bactericide, Wood Preservative
- Human Data
- Mutation Data
- Natural Product
- Protein Synthesis Inhibitors
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Streptomycin
- Streptomycin [INN:BAN]
MeSH Heading
- Streptomycin
Synonyms
- 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside
- 4-18-00-07540 (Beilstein Handbook Reference)
- Agrept
- Agrimycin
- BRN 0074498
- Caswell No. 804
- CCRIS 5730
- D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-
- EINECS 200-355-3
- EPA Pesticide Chemical Code 006306
- Estreptomicina
- Estreptomicina [INN-Spanish]
- Gerox
- Hokko-mycin
- HSDB 1768
- Neodiestreptopab
- NSC 14083
- Strepcen
- Streptomicina
- Streptomicina [Italian]
- Streptomycin
- Streptomycin A
- Streptomycine
- Streptomycinum
- Streptomyzin
- Streptomyzin [German]
- UNII-Y45QSO73OB
Systematic Names
- D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-
- D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-
- Streptomycin
Superlist Name
- Streptomycin
Registry Numbers
CAS Registry Number
- 57-92-1
FDA UNII
- Y45QSO73OB
Other Registry Numbers
- 12672-24-1
- 47814-83-5
- 47816-81-9
- 82958-69-8
Related Registry Number
- 3810-74-0 (sulfate (2:3) salt)
System Generated Number
- 0000057921
Structure Descriptors
InChI
InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1InChIKey
UCSJYZPVAKXKNQ-HZYVHMACSA-NSmiles
CN[C@H]1[C@H](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intravenous | 150mg/kg (150mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. | |
cat | LDLo | oral | 2gm/kg (2000mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. | |
cat | LDLo | subcutaneous | 600mg/kg (600mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. | |
dog | LDLo | subcutaneous | 300mg/kg (300mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. | |
guinea pig | LDLo | subcutaneous | 600mg/kg (600mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. | |
human | TDLo | intraperitoneal | 143mg/kg (143mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | British Medical Journal. Vol. 1, Pg. 556, 1961. |
human | TDLo | oral | 400mg/kg/28D- (400mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGES IN VESTIBULAR FUNCTIONS: EAR | Revue Medicale de la Suisse Romande. Vol. 73, Pg. 854, 1953. |
human | TDLo | parenteral | 28mg/kg/D (28mg/kg) | BLOOD: EOSINOPHILIA | Revue Medicale de la Suisse Romande. Vol. 73, Pg. 820, 1953. |
monkey | LDLo | subcutaneous | 400mg/kg (400mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. | |
mouse | LD50 | intraperitoneal | 525mg/kg (525mg/kg) | Strahlentherapie. Vol. 127, Pg. 245, 1965. | |
mouse | LD50 | intravenous | 90200ug/kg (90.2mg/kg) | Antibiotiki. Vol. 18, Pg. 249, 1973. | |
mouse | LD50 | oral | 500mg/kg (500mg/kg) | Yakkyoku. Pharmacy. Vol. 38, Pg. 1493, 1987. | |
mouse | LD50 | subcutaneous | 520mg/kg (520mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 15, Pg. 496, 1960. | |
mouse | LD50 | unreported | 90mg/kg (90mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955. | |
rabbit | LDLo | intravenous | 175mg/kg (175mg/kg) | Naturwissenschaften. Vol. 43, Pg. 183, 1956. | |
rabbit | LDLo | subcutaneous | 600mg/kg (600mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. | |
rat | LD50 | oral | 9gm/kg (9000mg/kg) | "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revisionVol. 4, Pg. 35, 1976/1977. | |
rat | LDLo | intravenous | 175mg/kg (175mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. | |
rat | LDLo | subcutaneous | 600mg/kg (600mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | -7.530 | (none) | EST | |
Water Solubility | 1.00E+06 | mg/L | 25 | EST |
Vapor Pressure | 5.82E-28 | mm Hg | 25 | EST |
Henry's Law Constant | 8.41E-44 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 5.51E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.