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Substance Name: Tubocurarine chloride [INN]
RN: 57-94-3
UNII: 7BCM17J5YA
InChIKey: GXFZCDMWGMFGFL-KKXMJGKMSA-N

Note

  • A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C37-H41-N2-O6.Cl-H.Cl

Molecular Weight

  • 681.653
 
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Names and Synonyms

Results Name

  • Tubocurarine chloride [INN]

Name of Substance

  • Tubocurarine chloride (anhydrous)
  • Tubocurarine chloride [INN]

Synonyms

  • (+)-Tubocurarine chloride hydrochloride
  • 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, (13aR-(13aR*,25aS*))-
  • Amelizol
  • Chlorure de tubocurarine
  • Chlorure de tubocurarine [INN-French]
  • Cloruro de tubocurarina
  • Cloruro de tubocurarina [INN-Spanish]
  • Curarin-haf
  • d-(+)-Tubocurarine chloride
  • d-7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium chloride
  • d-Paracurarine chloride
  • D-Tubocurarine chloride
  • d-Tubocurarine dichloride
  • d-Tubocurarine hydrochloride
  • Delacurarine
  • Dextrotubocurarine chloride
  • EINECS 200-356-9
  • Intocostrine T
  • Tubadil
  • Tubarine
  • Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-, chloride, hydrochloride
  • Tubocurarina cloruro
  • Tubocurarina cloruro [DCIT]
  • Tubocurarine chloride
  • Tubocurarine hydrochloride
  • Tubocurarini chloridum
  • Tubocurarini chloridum [INN-Latin]
  • UNII-7BCM17J5YA

Systematic Names

  • 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, (13aR,25aS)-
  • Tubocurarine chloride
  • Tubocurarine, chloride, hydrochloride, (+)- (8CI)
  • Tubocurarine, dichloride, (+)-

Registry Numbers

CAS Registry Number

  • 57-94-3

FDA UNII

  • 7BCM17J5YA

Other Registry Numbers

  • 1406-69-5
  • 29132-50-1
  • 303-11-7
  • 64780-74-1

System Generated Number

  • 0000057943

Molecular Formulas

Molecular Formula

  • C37-H41-N2-O6.Cl-H.Cl

Molecular Formula Fragments

  • C37-H41-N2-O6
  • Cl
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1

InChIKey

GXFZCDMWGMFGFL-KKXMJGKMSA-N

Smiles

c12c3c(c(OC)cc2CC[N+]([C@@H]1Cc1cc(Oc2cc4[C@H](Cc5ccc(O3)cc5)[N@@H+](CCc4cc2OC)C)c(O)cc1)(C)C)O.[ClH-].[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 66ug/kg (0.066mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 516, 1949.
mouse LD50 intramuscular 540ug/kg (0.54mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(12), Pg. 24, 1990.
mouse LD50 intraperitoneal 420ug/kg (0.42mg/kg)   Russian Pharmacology and Toxicology Vol. 32, Pg. 74, 1969.
mouse LD50 intravenous 97ug/kg (0.097mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 191, 1957.
mouse LD50 oral 33mg/kg (33mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965.
mouse LD50 subcutaneous 640ug/kg (0.64mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 117, 1975.
rabbit LD50 intravenous 170ug/kg (0.17mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(12), Pg. 24, 1990.
rat LD50 intraperitoneal 340ug/kg (0.34mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 117, 1975.
rat LD50 intravenous 66ug/kg (0.066mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 117, 1975.
rat LD50 oral 28mg/kg (28mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965.
rat LD50 subcutaneous 310ug/kg (0.31mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 117, 1975.