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Substance Name: Tiapamil hydrochloride [USAN]
RN: 57010-32-9
UNII: S3R8JZ9DJH
InChIKey: FEEDFNKRGAKOFI-UHFFFAOYSA-N

Note

  • Calcium antagonist.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C26-H37-N-O8-S2.Cl-H

Molecular Weight

  • 592.17
 
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Names and Synonyms

Name of Substance

  • Tiapamil hydrochloride [USAN]

Synonyms

  • Dimeditiapramine
  • EINECS 260-511-1
  • Larocord
  • Ro 11-1781
  • Tiapamil HCl
  • Tiapamil hydrochloride
  • UNII-S3R8JZ9DJH

Systematic Names

  • ((3,4-Dimethoxyphenethyl)(2-(2,3-dimethoxyphenyl)-1,3-dithian-2-yl)propyl)methylammonium chloride 1,1,3,3-tetraoxide
  • 1,3-Dithiane-2-propanamine, 2-(3,4-dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-N-methyl-, 1,1,3,3-tetraoxide, hydrochloride
  • m-Dithiane-2-propylamine, N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-, 1,1,3,3-tetraoxide, hydrochloride

Registry Numbers

CAS Registry Number

  • 57010-32-9

FDA UNII

  • S3R8JZ9DJH

Other Registry Number

  • 67418-30-8

Related Registry Number

  • 57010-31-8 (Parent)

System Generated Number

  • 0057010329

Molecular Formulas

Molecular Formula

  • C26-H37-N-O8-S2.Cl-H

Molecular Formula Fragments

  • C26-H37-N-O8-S2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C26H37NO8S2.ClH/c1-27(15-12-20-8-10-22(32-2)24(18-20)34-4)14-6-13-26(36(28,29)16-7-17-37(26,30)31)21-9-11-23(33-3)25(19-21)35-5;/h8-11,18-19H,6-7,12-17H2,1-5H3;1H

InChIKey

FEEDFNKRGAKOFI-UHFFFAOYSA-N

Smiles

C1(c2cc(c(OC)cc2)OC)(S(CCCS1(=O)=O)(=O)=O)CCC[N@@H+](CCc1cc(c(OC)cc1)OC)C.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1401, 1981.
mouse LD50 intravenous 40mg/kg (40mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1401, 1981.
mouse LD50 oral 581mg/kg (581mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1401, 1981.
mouse LD50 subcutaneous 347mg/kg (347mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1401, 1981.
rat LD50 intraperitoneal 455mg/kg (455mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1401, 1981.
rat LD50 intravenous 84mg/kg (84mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1401, 1981.
rat LD50 oral 1803mg/kg (1803mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1401, 1981.
rat LD50 subcutaneous 546mg/kg (546mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1401, 1981.