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Substance Name: Clorazepate dipotassium [USAN:USP:JAN]
RN: 57109-90-7
UNII: 63FN7G03XY
InChIKey: QCHSEDTUUKDTIG-UHFFFAOYSA-L

Note

  • A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.

Molecular Formulas

  • C16-H10-Cl-N2-O3.K.H-K-O
  • C16-H11-Cl-K2-N2-O4
  • C16-H11-Cl-N2-O3.H-K-O.K

Molecular Weight

  • 408.9219
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Human Data
  • Mutation Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizer (Minor)
  • Tranquilizing Agents

Superlist Classification Code

  • DEA Schedule IV

Names and Synonyms

Name of Substance

  • Clorazepate dipotassium [USAN:USP:JAN]
  • Dipotassium clorazepate [INN]

MeSH Heading

  • Clorazepate dipotassium

Synonyms

  • 1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, potassium salt compound with potassium hydroxide (1:1)
  • 4306 CB
  • AB 35616
  • Abbott-35616
  • AH 3232
  • Belseren
  • Bipotassium chlorazepate
  • CB 4306
  • Chlorazepam
  • Chlorazepate
  • Chlorazepate dipotassium
  • Clorazepate acid dipotassium salt
  • Clorazepate dipotassique
  • Clorazepate dipotassique [INN-French]
  • Clorazepate dipotassium
  • Clorazepato
  • Clorazepato dipotasico
  • Clorazepato dipotasico [INN-Spanish]
  • Clorazepato [DCIT]
  • Dikalii clorazepas
  • Dikalii clorazepas [INN-Latin]
  • Dipotassium chlorazepate
  • Dipotassium clorazepate
  • EINECS 260-565-6
  • Gen-Xene
  • Mendon
  • Modiur
  • Nevracten
  • Potassium 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate compound with potassium hydroxide (1:1)
  • Softramal
  • Tencilan
  • TR 19119
  • Tranex
  • Transilium
  • Tranxene
  • Tranxene SD
  • Tranxilen
  • Tranxilene
  • Tranxilium
  • UNII-63FN7G03XY

Systematic Names

  • 1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, monopotassium salt, compd. with potassium hydroxide (K(OH)) (1:1)
  • 1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, potassium salt compd. with potassium hydroxide (1:1)
  • Dipotassium clorazepate

Superlist Names

  • Clorazepate
  • Clorazepate dipotassium
  • DEA No. 2768
  • Tranxene

Registry Numbers

CAS Registry Number

  • 57109-90-7

FDA UNII

  • 63FN7G03XY

Other Registry Number

  • 27665-58-3

System Generated Number

  • 0057109907

Molecular Formulas

Molecular Formulas

  • C16-H10-Cl-N2-O3.K.H-K-O
  • C16-H11-Cl-K2-N2-O4
  • C16-H11-Cl-N2-O3.H-K-O.K

Molecular Formula Fragments

  • C16-H10-Cl-N2-O3
  • C16-H11-Cl-N2-O3
  • COMPONENT
  • H-K-O
  • K

Structure Descriptors

InChI

1S/C16H11ClN2O3.2K.H2O/c17-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)19-14(16(21)22)15(20)18-12;;;/h1-8,14H,(H,18,20)(H,21,22);;;1H2/q;2*+1;/p-2

InChIKey

QCHSEDTUUKDTIG-UHFFFAOYSA-L

Smiles

[K+].O[K].[O-]C(=O)C1N=C(c2ccccc2)c3cc(Cl)ccc3NC1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 290mg/kg (290mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SLEEP
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 123, 1970.
mouse LD50 intravenous 173mg/kg (173mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 603, 1973.
mouse LD50 oral 700mg/kg (700mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 123, 1970.
mouse LD50 subcutaneous 510mg/kg (510mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 603, 1973.
rat LD50 intraperitoneal 31200ug/kg (31.2mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979.
rat LD50 intravenous 279mg/kg (279mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 603, 1973.
rat LD50 oral 880mg/kg (880mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979.
rat LD50 subcutaneous 1478mg/kg (1478mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 603, 1973.