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Substance Name: Acetophenazine maleate [USAN:USP]
RN: 5714-00-1
UNII: 3P5HNU5JTC
InChIKey: NUKVZKPNSKJGBK-SPIKMXEPSA-N

Classification Codes

  • Antipsychotic
  • Drug / Therapeutic Agent
  • Skin / Eye Irritant

Molecular Formula

  • C23-H29-N3-O2-S.2C4-H4-O4

Molecular Weight

  • 643.7103
 
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Names and Synonyms

Name of Substance

  • Acetophenazine dimaleate
  • Acetophenazine maleate [USAN:USP]

Synonyms

  • 1-(10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)-10H-phenothiazin-2-yl)ethanone
  • 1-(2-Hydroxyethyl)-4-(3-(2-acetyl-10-phenothiazinyl)propyl)piperazine dimaleate
  • 10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl methyl ketone dimaleate
  • 10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl methyl ketone maleate (1:2) (salt)
  • 2-Acetyl-10-(3-(4-(beta-hydroxyethyl)piperazinyl)propyl)phenothiazine dimaleate
  • Acetophazine maleate
  • Acetophenazine dimaleate
  • Acetophenazine maleate
  • EINECS 227-202-3
  • Ethanone, 1-(10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-10H-phenothiazin-2-yl)-, (Z) 2-butenedioate (1:2) (salt)
  • NSC 169180
  • NSC 70600
  • Phentoxate
  • SC 8806
  • Sch 6673
  • Tindal
  • Tindal maleate
  • Tindala
  • UNII-3P5HNU5JTC

Systematic Names

  • 2-Acetyl-10-(3-(4-(2-hydroxyethyl)piperazinyl)propyl)-10H-phenothiazine dimaleate
  • Ethanone, 1-(10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-10H-phenothiazin-2-yl)-, (Z)-2-butenedioate (1:2) (salt)
  • Ketone, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl methyl, dimaleate
  • Ketone, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl methyl, maleate (1:2) (salt) (8CI)

Registry Numbers

CAS Registry Number

  • 5714-00-1

FDA UNII

  • 3P5HNU5JTC

Related Registry Number

  • 2751-68-0 (Parent)

System Generated Number

  • 0005714001

Molecular Formulas

Molecular Formula

  • C23-H29-N3-O2-S.2C4-H4-O4

Molecular Formula Fragments

  • C23-H29-N3-O2-S
  • C4-H4-O4

Structure Descriptors

InChI

1S/C23H29N3O2S.2C4H4O4/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27;2*5-3(6)1-2-4(7)8/h2-3,5-8,17,27H,4,9-16H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

InChIKey

NUKVZKPNSKJGBK-SPIKMXEPSA-N

Smiles

CC(=O)c1cc2c(cc1)Sc3c(cccc3)N2CCCN4CCN(CC4)CCO.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 75mg/kg (75mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
mouse LD50 intravenous 71mg/kg (71mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01100,
rat LD50 intraperitoneal 60mg/kg (60mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 11, 1972.
rat LD50 intravenous 39mg/kg (39mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 11, 1972.
rat LD50 oral 415mg/kg (415mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 11, 1972.