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Substance Name: Naftopidil [INN]
RN: 57149-07-2
UNII: R9PHW59SFN
InChIKey: HRRBJVNMSRJFHQ-UHFFFAOYSA-N

Molecular Formula

  • C24-H28-N2-O3

Molecular Weight

  • 392.496
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Hematologic Agents
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Platelet Aggregation Inhibitors
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Naftopidil
  • Naftopidil (unspecified)
  • Naftopidil [INN]

Synonyms

  • (+-)-1-(4-(2-Methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol
  • (+-)-4-(o-Methoxyphenyl)-alpha-((1-naphthyloxy)methyl)-1-piperazineethanol
  • (RS)-1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol
  • 4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol
  • 5-23-02-00135 (Beilstein Handbook Reference)
  • BRN 0629965
  • KT-611
  • Naftopidil
  • Naftopidilum
  • Naftopidilum [Latin]
  • UNII-R9PHW59SFN

Systematic Names

  • (+-)-4-(o-Methoxyphenyl)-alpha-((1-naphthyloxy)methyl)-1-piperazineethanol
  • 1-Pioerazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-

Registry Numbers

CAS Registry Number

  • 57149-07-2

FDA UNII

  • R9PHW59SFN

System Generated Number

  • 0057149072

Structure Descriptors

InChI

1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3

InChIKey

HRRBJVNMSRJFHQ-UHFFFAOYSA-N

Smiles

c1ccc2ccccc2c1OC[C@@H](CN1CCN(CC1)c1c(cccc1)OC)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 5gm/kg (5000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 41, Pg. 2404, 1999.
rat LD50 oral > 5gm/kg (5000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 41, Pg. 2404, 1999.