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Substance Name: Sulfamoxole mixture with trimethoprim
RN: 57197-43-0
InChIKey: QSCDJPXGCZNSNJ-UHFFFAOYSA-N

Note

  • Usually a mixture of 5 parts of sulfamoxole and 1 part of trimethoprim.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C14-H18-N4-O3.C11-H13-N3-O3-S

Molecular Weight

  • 557.629
 
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Names and Synonyms

Results Name

  • Sulfamoxole mixture with trimethoprim

Name of Substance

  • Sulfamoxole mixture with trimethoprim
  • Sulfamoxole, trimethoprim drug combination

Synonyms

  • CN 3123
  • Co-trifamole
  • Cotrifamole
  • Nevin (mixture)
  • Sulfamoxazole + trimethoprim
  • Sulfamoxole and trimethoprim
  • Sulfamoxole-trimethoprim mixture
  • Supristol
  • Trimethoprim and sulfamoxole
  • Trimethoprim-sulfamoxole mixture

Systematic Name

  • Benzenesulfonamide, 4-amino-N-(4,5-dimethyl-2-oxazolyl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine

Registry Numbers

CAS Registry Number

  • 57197-43-0

System Generated Number

  • 0057197430

Molecular Formulas

Molecular Formula

  • C14-H18-N4-O3.C11-H13-N3-O3-S

Molecular Formula Fragments

  • C11-H13-N3-O3-S
  • C14-H18-N4-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C14H18N4O3.C11H13N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-8(2)17-11(13-7)14-18(15,16)10-5-3-9(12)4-6-10/h5-7H,4H2,1-3H3,(H4,15,16,17,18);3-6H,12H2,1-2H3,(H,13,14)

InChIKey

QSCDJPXGCZNSNJ-UHFFFAOYSA-N

Smiles

c1(Cc2c(nc(N)nc2)N)cc(c(c(c1)OC)OC)OC.c1(oc(c(n1)C)C)NS(c1ccc(cc1)N)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
mouse LD50 intraperitoneal 1870mg/kg (1870mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
mouse LD50 oral > 12gm/kg (12000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
rat LD50 intraperitoneal 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
rat LD50 oral 14gm/kg (14000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.