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Substance Name: Pamidronate disodium anhydrous
RN: 57248-88-1
UNII: C7S8VWP5DH
InChIKey: CEYUIFJWVHOCPP-UHFFFAOYSA-L

Note

  • Inhibits osteolytic bone lesions; inhibits the mevalonate pathway, which is required for the prenylation of the small GTPase.

Molecular Formulas

  • C3-H11-N-O7-P2.2Na
  • C3-H9-N-O7-P2.2Na

Molecular Weight

  • 279.0321
 

Classification Codes

  • Bone Resorption Inhibitor
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Pamidronate disodium anhydrous

Synonyms

  • (3-Amino-1-hydroxypropylidene)diphosphonic acid disodium salt
  • Aminohydroxypropylidene diphosphonate disodium salt
  • Aminomux
  • APD
  • Aredia
  • CGP 23339 A
  • CGP 23339A
  • CGP 23339AE
  • Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate
  • Disodium pamidronate
  • EINECS 260-647-1
  • Pamidronate disodium
  • Pamidronic acid disodium salt
  • UNII-C7S8VWP5DH

Systematic Names

  • 3-Amino-1-hydroxypropane-1,1-diphosphonic acid disodium salt
  • Disodium dihydrogen (3-amino-1-hydroxypropylidene)bisphosphonate
  • Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt

Registry Numbers

CAS Registry Number

  • 57248-88-1

FDA UNII

  • C7S8VWP5DH

Related Registry Number

  • 40391-99-9 (Parent)

System Generated Number

  • 0057248881

Molecular Formulas

Molecular Formulas

  • C3-H11-N-O7-P2.2Na
  • C3-H9-N-O7-P2.2Na

Molecular Formula Fragments

  • C3-H11-N-O7-P2
  • C3-H9-N-O7-P2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2

InChIKey

CEYUIFJWVHOCPP-UHFFFAOYSA-L

Smiles

C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 20mg/kg (20mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 2408, 1994.
man TDLo oral 750ug/kg/5D-I (0.75mg/kg) SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE

SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Australian and New Zealand Journal of Medicine. Vol. 24, Pg. 320, 1994.
mouse LD50 intraperitoneal 190mg/kg (190mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 intravenous 45mg/kg (45mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 oral 625mg/kg (625mg/kg)   British UK Patent Application. Vol. #2096889,
rat LD50 intravenous 50mg/kg (50mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 2408, 1994.
women TDLo intravenous 600ug/kg/6H-C (0.6mg/kg)   Lancet. Vol. 1, Pg. 622, 1987.
women TDLo intravenous 900ug/kg (0.9mg/kg) MUSCULOSKELETAL: JOINTS Annals of Pharmacotherpy. Vol. 31, Pg. 499, 1997.