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Substance Name: Ridaforolimus [USAN:INN]
RN: 572924-54-0
UNII: 48Z35KB15K
InChIKey: BUROJSBIWGDYCN-GAUTUEMISA-N

Notes

  • An mTOR inhibitor for the treatment of cancer.
  • An mTOR inhibitor for the treatment of cancer.

    NCI: A small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and,consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway. (NCI Thesaurus)

Molecular Formula

  • C53-H84-N-O14-P

Molecular Weight

  • 990.2136
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Results Name

  • Ridaforolimus [USAN:INN]

Name of Substance

  • Ridaforolimus
  • Ridaforolimus [USAN:INN]

Synonyms

  • (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-12-((1R)-2- ((1S,3R,4R)-4-((Dimethylphosphinoyl)oxy)-3-methoxycyclohexyl)-1-methylethyl)-1,18- dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4- azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene- 2,3,10,14,20-pentone
  • AP 23573
  • AP23573
  • Deforolimus
  • MK 8669
  • MK-8669
  • MK8669
  • Ridaforolimus
  • Taltorvic
  • UNII-48Z35KB15K

Systematic Name

  • Rapamycin, 42-(dimethylphosphinate)

Registry Numbers

CAS Registry Number

  • 572924-54-0

FDA UNII

  • 48Z35KB15K

Other Registry Number

  • 697252-87-2

System Generated Number

  • 0572924540

Structure Descriptors

InChI

1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61,67-40)50(58)51(59)54-25-17-16-20-41(54)52(60)66-45(35(4)28-39-22-24-43(46(29-39)64-9)68-69(11,12)62)31-42(55)34(3)27-37(6)48(57)49(65-10)47(56)36(5)26-32/h13-15,18-19,27,32,34-36,38-41,43-46,48-49,57,61H,16-17,20-26,28-31H2,1-12H3/b15-13+,18-14+,33-19+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

InChIKey

BUROJSBIWGDYCN-GAUTUEMISA-N

Smiles

C1CCN2[C@@H](C1)C(=O)O[C@@H](CC(=O)[C@@H](C=C([C@H]([C@H](C(=O)[C@@H](C[C@@H](C=CC=CC=C([C@H](C[C@@H]1CC[C@H]([C@](C(=O)C2=O)(O1)O)C)OC)C)C)C)OC)O)C)C)[C@H](C)C[C@@H]1CC[C@H]([C@@H](C1)OC)OP(=O)(C)C