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Substance Name: Theophylline olamine [USP]
RN: 573-41-1
UNII: 9Z1S0O31SL
InChIKey: DAAFJZUNCOXSKD-UHFFFAOYSA-N

Note

  • A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLATE CYCLASE and cyclic AMP.

Molecular Formula

  • C7-H8-N4-O2.C2-H7-N-O

Molecular Weight

  • 241.249
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Theophylline ethanolamine
  • Theophylline olamine
  • Theophylline olamine [USP]

Synonyms

  • Clysmathane
  • EINECS 209-355-8
  • Ethanol, 2-amino-, compd. with theophylline (1:1)
  • Fleet-theophylline
  • Monotheamin
  • Monotheamine
  • Monoxantil
  • Theamin
  • Theophylline compound with 2-aminoethanol (1:1)
  • Theophylline ethanolamine
  • Theophylline monoethanolamine
  • Theophylline olamine
  • Theopylline monoethanolamine
  • UNII-9Z1S0O31SL
  • Unophyllin

Systematic Names

  • 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 2-aminoethanol (1:1)
  • Theophylline 2-aminoethanol
  • Theophylline, compd. with 2-aminoethanol (1:1)

Registry Numbers

CAS Registry Number

  • 573-41-1

FDA UNII

  • 9Z1S0O31SL

System Generated Number

  • 0000573411

Molecular Formulas

Molecular Formula

  • C7-H8-N4-O2.C2-H7-N-O

Molecular Formula Fragments

  • C2-H7-N-O
  • C7-H8-N4-O2
  • COMPONENT

Structure Descriptors

InChI

1S/C7H8N4O2.C2H7NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h3H,1-2H3,(H,8,9);4H,1-3H2

InChIKey

DAAFJZUNCOXSKD-UHFFFAOYSA-N

Smiles

c12c(nc[nH]2)n(c(=O)n(c1=O)C)C.C(CO)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LDLo intravenous 190mg/kg (190mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 45, Pg. 1, 1932.