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Substance Name: Carbidopa mixture with Levodopa
RN: 57308-51-7
InChIKey: IVTMXOXVAHXCHI-YXLMWLKOSA-N

Note

  • Contains levodopa & carbidopa.

Molecular Formula

  • C9-H11-N-O4.C10-H14-N2-O4

Molecular Weight

  • 423.4195
 

Classification Codes

  • Adjuvants, Immunologic
  • Anti-Dyskinesia Agents
  • Antiparkinson Agents
  • Central Nervous System Agents
  • Dopamine Agents
  • Dopamine Agonists
  • Drug / Therapeutic Agent
  • Human Data
  • Immunologic Factors
  • Neurotransmitter Agents

Names and Synonyms

Results Name

  • Carbidopa mixture with Levodopa

Name of Substance

  • Carbidopa, levodopa drug combination

Synonyms

  • Carbidopa / Levodopa
  • Carbidopa and Levodopa
  • Carbidopa-L-dopa mixt.
  • Carbidopa-levodopa (1:10)
  • Carbidopa-levodopa ER
  • Carbidopa-levodopa extended release
  • Carbidopa-levodopa mixt.
  • Carbilev
  • CHF 1512
  • Co-careldopa
  • DM-1992
  • Dopabain
  • Duodopa
  • Duopa
  • IPX 066
  • IPX066
  • Isicom
  • Levodopa / carbidopa
  • Levodopa-carbidopa (10:1)
  • Levodopa/Carbidopa Solution
  • Nacom
  • Nakom
  • ND 0612
  • ND0612
  • Parcopa
  • Rytary
  • Sinemet
  • Sinemet CR

Systematic Names

  • L-Tyrosine, 3-hydroxy-, mixt. with (S)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid
  • L-Tyrosine, 3-hydroxy-, mixt. with (S)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid (10:1)

Registry Numbers

CAS Registry Number

  • 57308-51-7

Other Registry Number

  • 500019-90-9

System Generated Number

  • 0057308517

Molecular Formulas

Molecular Formula

  • C9-H11-N-O4.C10-H14-N2-O4

Molecular Formula Fragments

  • C10-H14-N2-O4
  • C9-H11-N-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C10H14N2O4.C9H11NO4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h2-4,12-14H,5,11H2,1H3,(H,15,16);1-2,4,6,11-12H,3,10H2,(H,13,14)/t10-;6-/m00/s1

InChIKey

IVTMXOXVAHXCHI-YXLMWLKOSA-N

Smiles

C[C@](Cc1ccc(c(c1)O)O)(C(=O)O)NN.c1cc(c(cc1C[C@@H](C(=O)O)N)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 206mg/kg (206mg/kg) BEHAVIORAL: ATAXIA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

GASTROINTESTINAL: NAUSEA OR VOMITING
Khigiena i Zdraveopazvane. Hygiene and Sanitation. Vol. 33(4), Pg. 38, 1990.
mouse LD50 oral > 3055mg/kg (3055mg/kg)   Drugs in Japan Vol. 6, Pg. 907, 1982.
rat LD50 oral 1319mg/kg (1319mg/kg)   Drugs in Japan Vol. 6, Pg. 907, 1982.