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Substance Name: Tolonidine nitrate
RN: 57524-15-9
UNII: 75W1B0GTHA
InChIKey: SEIGDXGATKHXKR-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H12-Cl-N3.H-N-O3

Molecular Weight

  • 272.6907
 
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Names and Synonyms

Name of Substance

  • Tolonidine nitrate

Synonyms

  • 2-(2-Chloro-p-toluidino)-2-imidazoline nitrate
  • CERM 10,137
  • EINECS 260-785-2
  • Euctan
  • Tolonidine nitrate
  • UNII-75W1B0GTHA

Systematic Names

  • 1H-Imidazol-2-amine, 4,5-dihydro-N-(2-chloro-4-methylphenyl)-, mononitrate
  • N-(2-Chloro-p-tolyl)-4,5-dihydro-1H-imidazol-2-amine mononitrate

Registry Numbers

CAS Registry Number

  • 57524-15-9

FDA UNII

  • 75W1B0GTHA

Related Registry Number

  • 4201-22-3 (Parent)

System Generated Number

  • 0057524159

Molecular Formulas

Molecular Formula

  • C10-H12-Cl-N3.H-N-O3

Molecular Formula Fragments

  • C10-H12-Cl-N3
  • COMPONENT
  • H-N-O3

Structure Descriptors

InChI

1S/C10H12ClN3.HNO3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10;2-1(3)4/h2-3,6H,4-5H2,1H3,(H2,12,13,14);(H,2,3,4)

InChIKey

SEIGDXGATKHXKR-UHFFFAOYSA-N

Smiles

Cc1ccc(c(c1)Cl)NC2=NCCN2.[N+](=O)(O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 18500ug/kg (18.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1926, 1975.
mouse LD50 oral 160mg/kg (160mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1926, 1975.
rat LD50 intravenous 42mg/kg (42mg/kg) BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1926, 1975.
rat LD50 oral 420mg/kg (420mg/kg) BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1926, 1975.