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Substance Name: Amineptine [INN]
RN: 57574-09-1
UNII: 27T1I13L6G
InChIKey: ONNOFKFOZAJDHT-UHFFFAOYSA-N

Note

  • Used in treatment of neuroses with psychoasthenic, anxio-phobic & depressive manifestations.

Molecular Formula

  • C22-H27-N-O2

Molecular Weight

  • 337.4603
 

Classification Codes

  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Psychotropic Drugs
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Names and Synonyms

Name of Substance

  • Amineptin
  • Amineptine [INN]

Synonyms

  • 7-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid
  • Amineptin
  • Amineptine
  • Amineptino
  • Amineptino [INN-Spanish]
  • Amineptinum
  • Amineptinum [INN-Latin]
  • BRN 2170218
  • EINECS 260-818-0
  • EU 1694
  • S 1694
  • Survector
  • UNII-27T1I13L6G

Systematic Names

  • 7-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid
  • Amineptine
  • Heptanoic acid, 7-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)-

Registry Numbers

CAS Registry Number

  • 57574-09-1

FDA UNII

  • 27T1I13L6G

Related Registry Number

  • 30272-08-3 (hydrochloride)

System Generated Number

  • 0057574091

Structure Descriptors

InChI

1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)

InChIKey

ONNOFKFOZAJDHT-UHFFFAOYSA-N

Smiles

C1(c2c(CCc3c1cccc3)cccc2)NCCCCCCC(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 115mg/kg (115mg/kg)   Journal de Pharmacologie. Vol. 17, Pg. 37, 1986.
women TDLo oral 84mg/kg/2W-I (84mg/kg)   Gut. Vol. 27, Pg. 726, 1986.
women TDLo oral 84mg/kg/2W-I (84mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LIVER: LIVER FUNCTION TESTS IMPAIRED
Gut. Vol. 27, Pg. 726, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.660 (none)   EST
Atmospheric OH Rate Constant 1.13E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.