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Substance Name: Amineptine [INN]
RN: 57574-09-1
UNII: 27T1I13L6G
InChIKey: ONNOFKFOZAJDHT-UHFFFAOYSA-N
Note
- Used in treatment of neuroses with psychoasthenic, anxio-phobic & depressive manifestations.
Molecular Formula
- C22-H27-N-O2
Molecular Weight
- 337.4603
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Human Data
- Psychotropic Drugs
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Names and Synonyms
Name of Substance
- Amineptin
- Amineptine [INN]
Synonyms
- 7-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid
- Amineptin
- Amineptine
- Amineptino
- Amineptino [INN-Spanish]
- Amineptinum
- Amineptinum [INN-Latin]
- BRN 2170218
- EINECS 260-818-0
- EU 1694
- S 1694
- Survector
- UNII-27T1I13L6G
Systematic Names
- 7-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid
- Amineptine
- Heptanoic acid, 7-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)-
Registry Numbers
CAS Registry Number
- 57574-09-1
FDA UNII
- 27T1I13L6G
Related Registry Number
- 30272-08-3 (hydrochloride)
System Generated Number
- 0057574091
Structure Descriptors
InChI
1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)InChIKey
ONNOFKFOZAJDHT-UHFFFAOYSA-NSmiles
C1(c2c(CCc3c1cccc3)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 115mg/kg (115mg/kg) | Journal de Pharmacologie. Vol. 17, Pg. 37, 1986. | |
women | TDLo | oral | 84mg/kg/2W-I (84mg/kg) | Gut. Vol. 27, Pg. 726, 1986. | |
women | TDLo | oral | 84mg/kg/2W-I (84mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: LIVER FUNCTION TESTS IMPAIRED | Gut. Vol. 27, Pg. 726, 1986. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 2.660 | (none) | EST | |
Atmospheric OH Rate Constant | 1.13E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.