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Substance Name: Clebopride malate [JAN]
RN: 57645-91-7
UNII: H9490V5216
InChIKey: NYNKCGWJPNZJMI-UHFFFAOYSA-N

Classification Code

  • Reproductive Effect

Molecular Formula

  • C20-H24-Cl-N3-O2.C4-H6-O5

Molecular Weight

  • 507.968
 
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Names and Synonyms

Name of Substance

  • Clebopride malate
  • Clebopride malate [JAN]

Synonyms

  • 4-Amino-5-chloro-2-methoxy-N-(1-benzyl-4-piperidyl)benzamide malate
  • Clebopride hydrogen malate
  • Clebopride malate
  • EINECS 260-874-6
  • UNII-H9490V5216

Systematic Names

  • Benzamide, 4-amino-5-chloro-2-methoxy-N-(1-benzyl-4-piperidyl)-, malate
  • Malic acid, compound with 4-amino-N-(1-(benzyl)piperidin-4-yl)-5-chloro-2-methoxybenzamide (1:1)

Registry Numbers

CAS Registry Number

  • 57645-91-7

FDA UNII

  • H9490V5216

System Generated Number

  • 0057645917

Molecular Formulas

Molecular Formula

  • C20-H24-Cl-N3-O2.C4-H6-O5

Molecular Formula Fragments

  • C20-H24-Cl-N3-O2
  • C4-H6-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C20H24ClN3O2.C4H6O5/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14;5-2(4(8)9)1-3(6)7/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25);2,5H,1H2,(H,6,7)(H,8,9)

InChIKey

NYNKCGWJPNZJMI-UHFFFAOYSA-N

Smiles

c1(c(cc(c(c1)Cl)N)OC)C(NC1CC[NH+](CC1)Cc1ccccc1)=O.C([C@@H](C(=O)[O-])O)C(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 800mg/kg (800mg/kg)   Drugs in Japan Vol. -, Pg. 331, 1990.
mouse LD50 intramuscular 260mg/kg (260mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
mouse LD50 intraperitoneal 145mg/kg (145mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
mouse LD50 intravenous 51mg/kg (51mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
mouse LD50 oral 490mg/kg (490mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ANTIPSYCHOTIC
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
mouse LD50 subcutaneous 305mg/kg (305mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
rat LD50 intramuscular 1450mg/kg (1450mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
rat LD50 intraperitoneal 155mg/kg (155mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
rat LD50 intravenous 39mg/kg (39mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANALGESIA

GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
rat LD50 oral 2540mg/kg (2540mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.
rat LD50 subcutaneous 4850mg/kg (4850mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 803, 1983.