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Substance Name: Docusate sodium [USAN:USP:INN:BAN]
RN: 577-11-7
UNII: F05Q2T2JA0
InChIKey: APSBXTVYXVQYAB-UHFFFAOYSA-M

Note

  • All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.

Molecular Formula

  • C20-H38-O7-S.Na

Molecular Weight

  • 444.5613
 

Classification Codes

  • Pharmaceutic Aid (Surfactant)
  • Reproductive Effect
  • Skin / Eye Irritant
  • Stool Softener
  • Surface-Active Agents

Names and Synonyms

Name of Substance

  • 1,4-Bis(2-ethylhexyl)sulfobutanedioate, sodium salt
  • Bis(2-ethylhexyl) sodium sulfosuccinate
  • Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
  • Di-(2-ethylhexyl) sodium sulfosuccinate
  • Dioctyl sodium sulfosuccinate
  • Docusate sodium
  • Docusate sodium [USAN:USP:INN:BAN]
  • Sodium di-(2-ethylhexyl) sulfosuccinate
  • Sodium dioctyl sulfosuccinate
  • Sulfosuccinic acid, di-(2-ethylhexyl) ester, sodium salt

Synonyms

  • 1,4-Bis(2-ethylhexyl) sodium sulfosuccinate
  • 2-Ethylhexyl sulfosuccinate sodium
  • Adekacol EC 8600
  • Aerosol A 501
  • Aerosol AOT
  • Aerosol GPG
  • Aerosol OT
  • Aerosol OT 70PG
  • Aerosol OT 75
  • Aerosol OT-A
  • Aerosol OT-B
  • AI3-00239
  • Alcopol O
  • Alkasurf SS-O 75
  • Alphasol OT
  • Berol 478
  • Bis(2-ethylhexyl) S-sodium sulfosuccinate
  • Bis(2-ethylhexyl) sodium sulfosuccinate
  • Bis(2-ethylhexyl) sulfosuccinate sodium salt
  • Bis(2-ethylhexyl)sodium sulfosuccinate
  • Bis(ethylhexyl) ester of sodium sulfosuccinic acid
  • Bis-2-ethylhexylester sulfojantaranu sodneho
  • Bis-2-ethylhexylester sulfojantaranu sodneho [Czech]
  • Bloat treatment
  • Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
  • Celanol DOS 65
  • Celanol DOS 75
  • Clestol
  • Colace
  • Coloxyl
  • Complemix
  • Constonate
  • Coprol
  • Correctol Extra Gentle Tablets
  • Correctol Stool Softener Laxative
  • D-S-S
  • Defilin
  • DESS
  • Di(2-ethylhexyl)sulfosuccinic acid, sodium salt
  • Di-(2-ethylhexyl) sodium sulfosuccinate
  • Dialose
  • Dioctlyn
  • Dioctyl ester of sodium sulfosuccinate
  • Dioctyl ester of sodium sulfosuccinic acid
  • Dioctyl sodium sulfosuccinate
  • Dioctyl sodium sulphosuccinat
  • Dioctyl sodium sulphosuccinate
  • Dioctyl sulfosuccinate sodium
  • Dioctyl sulfosuccinate sodium salt
  • Dioctyl-medo forte
  • Dioctylal
  • Diomedicone
  • Diosuccin
  • Diotilan
  • Diovac
  • Diox
  • Disonate
  • Doc Q Lace
  • Docolace
  • Docuprene
  • Docusate sodique
  • Docusate sodique [INN-French]
  • Docusate sodium
  • Docusato sodico
  • Docusato sodico [INN-Spanish]
  • Docusatum natricum
  • Docusatum natricum [INN-Latin]
  • Doxinate
  • Doxol
  • DSS
  • Dulsivac
  • Duosol
  • EC 209-406-4
  • EINECS 209-406-4
  • HSDB 3065
  • Humifen WT 27G
  • Konlax
  • Kosate
  • Laxinate
  • Laxinate 100
  • Manoxal OT
  • Manoxol OT
  • Mervamine
  • Modane Soft
  • Molatoc
  • Molcer
  • Molofac
  • Monawet MD 70E
  • Monawet MO-70
  • Monawet MO-70 RP
  • Monawet MO-84 R2W
  • Monoxol OT
  • Natrii dioctylsulfosuccinas
  • Nekal WT-27
  • Nevax
  • Nikkol OTP 70
  • Norval
  • Obston
  • Rapisol
  • Regutol
  • Requtol
  • Revac
  • Sanmorin OT 70
  • SBO
  • Silace
  • Sobital
  • Sodium 1,4-bis(2-ethylhexyl) sulfosuccinate
  • Sodium 1,4-bis(2-ethylhexyl)sulfosuccinate
  • Sodium 2-ethylhexylsulfosuccinate
  • Sodium bis(2-ethylhexyl) sulfosuccinate
  • Sodium di-(2-ethylhexyl) sulfosuccinate
  • Sodium dioctyl sulfosuccinate
  • Sodium dioctyl sulphosuccinate
  • Sodium sulfodi-(2-ethylhexyl)-sulfosuccinate
  • Softil
  • Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego
  • Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego [Polish]
  • Soliwax
  • Solusol-100%
  • Solusol-75%
  • Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
  • Sulfimel DOS
  • Sulfosuccinic acid, bis(2-ethylhexyl)ester sodium salt
  • SV 102
  • Tex-Wet 1001
  • Triton GR 7
  • Triton GR-5
  • UNII-F05Q2T2JA0
  • Vatsol OT
  • Velmol
  • Waxsol
  • Wetaid SR

Systematic Names

  • Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)
  • Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
  • Docusate sodium
  • Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt

Superlist Names

  • Dioctyl sodium sulfosuccinate
  • Docusate sodium
  • Sodium bis(2-ethylhexyl)sulfosuccinate
  • Sodium di(2-ethylhexyl)sulfosuccinate
  • Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt

Mixture Names

  • Correctol Caplets
  • Correctol Tablets
  • D-S-S Plus
  • Dialose Plus
  • Dorbantyl
  • Doxan
  • Feen-a-Mint Pills
  • Ferro-Sequels
  • Folcal DHA
  • Folca[s care pme
  • Geriplex
  • Laxcaps
  • Modane Plus
  • Peri-Colace
  • Phillips Gelcaps
  • Prenexa
  • Purgasol
  • Senexon-S
  • Senna-S
  • Senokap DSS
  • Senokot S
  • Unilax
  • Vinacol

Registry Numbers

CAS Registry Number

  • 577-11-7

FDA UNII

  • F05Q2T2JA0

Other Registry Numbers

  • 105956-73-8
  • 106396-28-5
  • 110162-65-7
  • 113255-61-1
  • 12640-70-9
  • 130390-93-1
  • 133136-80-8
  • 135843-72-0
  • 138893-51-3
  • 141092-35-5
  • 1420177-77-0
  • 154608-80-7
  • 1644530-78-8
  • 201816-76-4
  • 202352-75-8
  • 209122-63-4
  • 209453-97-4
  • 2101416-24-2
  • 2152615-06-8
  • 29732-38-5
  • 336190-18-2
  • 51910-13-5
  • 52624-44-9
  • 53023-94-2
  • 56833-49-9
  • 59030-04-5
  • 590366-27-1
  • 60202-21-3
  • 66812-62-2
  • 67924-68-9
  • 75418-10-9
  • 76689-26-4
  • 78207-03-1
  • 835616-33-6

Related Registry Number

  • 10041-19-7 (Parent)

System Generated Number

  • 0000577117

Molecular Formulas

Molecular Formula

  • C20-H38-O7-S.Na

Molecular Formula Fragments

  • C20-H38-O7-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1

InChIKey

APSBXTVYXVQYAB-UHFFFAOYSA-M

Smiles

CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(=O)(=O)[O-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 60mg/kg (60mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 428, 1949.
mouse LD50 oral 2643mg/kg (2643mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Drug and Chemical Toxicology. Vol. 1, Pg. 89, 1977/1978.
rat LD50 intraperitoneal 590mg/kg (590mg/kg) VASCULAR: STRICTIRA; CJAMGES OM VESSE;S Bromatologia i Chemia Toksykologiczna. Vol. 7, Pg. 161, 1974.
rat LD50 oral 1900mg/kg (1900mg/kg)   Journal of the Society of Cosmetic Chemists. Vol. 13, Pg. 469, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 176 deg C   EXP
log P (octanol-water) 6.100 (none)   EST
Water Solubility 7.10E+04 mg/L 25 EXP
Vapor Pressure 2.17E-11 mm Hg 25 EST
Henry's Law Constant 5.00E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.30E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.