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Substance Name: Iodoalphionic acid [NF]
RN: 577-91-3
UNII: 060B6580LL
InChIKey: IKYIXZSIKOYSLD-UHFFFAOYSA-N

Note

  • Do not confuse biliognost with non-print entry term bilignost.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H12-I2-O3

Molecular Weight

  • 494.057
 
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Names and Synonyms

Name of Substance

  • Iodoalphionic acid
  • Iodoalphionic acid [NF]

Synonyms

  • 3,5-Diiodo-alpha-phenylphloretic acid
  • 4-10-00-01291 (Beilstein Handbook Reference)
  • AI3-15468
  • beta-(3,5-Diiodo-4-hydroxyphenyl)-alpha-phenylpropionic acid
  • beta-(4-Hydroxy-3,5-diiodophenyl)-alpha-phenylpropionic acid
  • beta-(4-Oxy-3,5-dijod-phenyl)-alpha-phenyl-propionsaeure
  • beta-(4-Oxy-3,5-dijod-phenyl)-alpha-phenyl-propionsaeure [German]
  • Biliognost
  • Biliselectan
  • Biliselktan
  • Bilitrast
  • Biselectan
  • BRN 2700381
  • Coletrast
  • Dikol
  • EINECS 209-417-4
  • Hydrocinnamic acid, 3,5-diiodo-4-hydroxy-alpha-phenyl-
  • Iodoalphionic acid
  • Iodobil
  • Jodobil
  • NSC 11854
  • Pheniodol
  • Pheniodolum
  • Priodax
  • Propionic acid, 3-(3,5-diiodo-4-hydroxyphenyl)-2-phenyl-
  • Tenamid
  • Tenicid
  • UNII-060B6580LL

Systematic Names

  • 3-(4-Hydroxy-3,5-diiodophenyl)-2-phenylpropionic acid
  • Benzenepropanoic acid, 4-hydroxy-3,5-diiodo-alpha-phenyl-
  • Hydrocinnamic acid, 3,5-diiodo-4-hydroxy-alpha-phenyl-
  • Propionic acid, 3-(4-hydroxy-3,5-diiodophenyl)-2-phenyl- (8CI)

Registry Numbers

CAS Registry Number

  • 577-91-3

FDA UNII

  • 060B6580LL

System Generated Number

  • 0000577913

Structure Descriptors

InChI

1S/C15H12I2O3/c16-12-7-9(8-13(17)14(12)18)6-11(15(19)20)10-4-2-1-3-5-10/h1-5,7-8,11,18H,6H2,(H,19,20)

InChIKey

IKYIXZSIKOYSLD-UHFFFAOYSA-N

Smiles

c1([C@@H](Cc2cc(c(O)c(c2)I)I)C(O)=O)ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Laboratory and Clinical Medicine. Vol. 27, Pg. 1376, 1942.
cat LDLo oral 500mg/kg (500mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Laboratory and Clinical Medicine. Vol. 27, Pg. 1376, 1942.
guinea pig LD50 intraperitoneal 930mg/kg (930mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
mouse LD50 intraperitoneal 640mg/kg (640mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
mouse LD50 intravenous 400mg/kg (400mg/kg)   Journal of Medicinal Chemistry. Vol. 13, Pg. 997, 1970.
mouse LD50 oral 2950mg/kg (2950mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
rat LD50 intraperitoneal 510mg/kg (510mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
rat LD50 intravenous 390mg/kg (390mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Klinische Wochenscrift. Vol. 20, Pg. 125, 1941.
rat LD50 oral 1100mg/kg (1100mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: MUSCLE WEAKNESS
Klinische Wochenscrift. Vol. 20, Pg. 125, 1941.
rat LD50 subcutaneous 540mg/kg (540mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Klinische Wochenscrift. Vol. 20, Pg. 125, 1941.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 164 deg C   EXP
log P (octanol-water) 5.410 (none)   EST
Atmospheric OH Rate Constant 9.67E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.