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Substance Name: Closantel [USAN:INN:BAN]
RN: 57808-65-8
UNII: EUL532EI54
InChIKey: JMPFSEBWVLAJKM-UHFFFAOYSA-N

Classification Codes

  • Anthelmintic
  • Anthelmintics
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Drug / Therapeutic Agent
  • Insecticides
  • Pesticides
  • Reproductive Effect

Molecular Formula

  • C22-H14-Cl2-I2-N2-O2

Molecular Weight

  • 663.071
 
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Names and Synonyms

Name of Substance

  • Closantel
  • Closantel [USAN:INN:BAN]

Synonyms

  • 5'-Chloro-alpha(sup 4)-(p-chlorophenyl)-alpha(sup 4)-cyano-3,5-diiodo-2',4'-salicyloxylidide
  • Benzamide, N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodo-
  • CCRIS 9345
  • Closantel
  • Closantelum
  • Closantelum [INN-Latin]
  • EINECS 260-967-1
  • N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide
  • NSC 335306
  • R 31,520
  • R 31520
  • UNII-EUL532EI54

Systematic Names

  • Benzamide, N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodo-
  • Closantel

Registry Numbers

CAS Registry Number

  • 57808-65-8

FDA UNII

  • EUL532EI54

System Generated Number

  • 0057808658

Structure Descriptors

InChI

1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)

InChIKey

JMPFSEBWVLAJKM-UHFFFAOYSA-N

Smiles

c1([C@@H](c2ccc(Cl)cc2)C#N)c(cc(NC(c2c(c(cc(c2)I)I)O)=O)c(c1)C)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cattle LDLo intramuscular 35mg/kg (35mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

BEHAVIORAL: MUSCLE WEAKNESS
Drug and Chemical Toxicology. Vol. 8, Pg. 101, 1985.
domestic animals - goat/sheep LDLo intramuscular 40mg/kg (40mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

BEHAVIORAL: MUSCLE WEAKNESS

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Drug and Chemical Toxicology. Vol. 8, Pg. 101, 1985.
domestic animals - goat/sheep LDLo oral 70mg/kg (70mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Drug and Chemical Toxicology. Vol. 8, Pg. 101, 1985.
mouse LD50 intramuscular 56800ug/kg (56.8mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Drug and Chemical Toxicology. Vol. 8, Pg. 101, 1985.
mouse LD50 oral 331mg/kg (331mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Drug and Chemical Toxicology. Vol. 8, Pg. 101, 1985.
mouse LD50 subcutaneous 67mg/kg (67mg/kg)   Veterinariya. Veterinary Science. Vol. 75(8), Pg. 23, 1998.
rat LD50 intramuscular 28400ug/kg (28.4mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Drug and Chemical Toxicology. Vol. 8, Pg. 101, 1985.
rat LD50 oral 262mg/kg (262mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Drug and Chemical Toxicology. Vol. 8, Pg. 101, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 217.8 deg C   EXP
log P (octanol-water) 8.110 (none)   EST
Atmospheric OH Rate Constant 1.54E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.