|
|
Substance Name: Domperidone [USAN:INN:BAN:JAN]
RN: 57808-66-9
UNII: 5587267Z69
InChIKey: FGXWKSZFVQUSTL-UHFFFAOYSA-N
Note
- A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Molecular Formula
- C22-H24-Cl-N5-O2
Molecular Weight
- 425.9176
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Emetic
- Antiemetics
- Autonomic Agents
- Central Nervous System Agents
- Dopamine Agents
- Dopamine Antagonists
- Drug / Therapeutic Agent
- Gastrointestinal Agents
- Human Data
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Reproductive Effect
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Domperidone
- Domperidone [USAN:INN:BAN:JAN]
MeSH Heading
- Domperidone
Synonyms
- 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-
- 5-24-02-00402 (Beilstein Handbook Reference)
- 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
- BRN 0903774
- Domperidona
- Domperidona [INN-Spanish]
- Domperidone
- Domperidonum
- Domperidonum [INN-Latin]
- EINECS 260-968-7
- KW-5338
- Motilium
- NSC 299589
- NSC 759575
- R 33,812
- UNII-5587267Z69
Systematic Names
- 2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-
- 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-
- Domperidone
Mixture Name
- Ovaprim
Registry Numbers
CAS Registry Number
- 57808-66-9
FDA UNII
- 5587267Z69
Related Registry Numbers
- 83898-65-1 (maleate (1:1))
- 99497-03-7 (maleate)
System Generated Number
- 0057808669
Structure Descriptors
InChI
InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)InChIKey
FGXWKSZFVQUSTL-UHFFFAOYSA-NSmiles
Clc1ccc2N(C3CCN(CCCN4C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 42700ug/kg (42.7mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: ANTIPSYCHOTIC GASTROINTESTINAL: NAUSEA OR VOMITING | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980. |
dog | LD50 | oral | > 160mg/kg (160mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980. | |
dog | LD50 | rectal | > 120mg/kg (120mg/kg) | Yakkyoku. Pharmacy. Vol. 35, Pg. 625, 1984. | |
dog | LD50 | subcutaneous | > 160mg/kg (160mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980. | |
guinea pig | LD50 | intravenous | 42900ug/kg (42.9mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ANTIPSYCHOTIC | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980. |
human | LDLo | intravenous | 429ug/kg (0.429mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | British Medical Journal. Vol. 288, Pg. 1728, 1984. |
human | TDLo | intravenous | 714ug/kg (0.714mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | British Medical Journal. Vol. 288, Pg. 1728, 1984. |
infant | TDLo | oral | 1170ug/kg/1D- (1.17mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Journal of Pediatrics. Vol. 108, Pg. 630, 1986. |
man | TDLo | intramuscular | 200ug/kg (0.2mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Lancet. Vol. 2, Pg. 1259, 1980. |
man | TDLo | oral | 234mg/kg/39W- (234mg/kg) | ENDOCRINE: GYNECOMASTIA | Postgraduate Medical Journal. Vol. 67, Pg. 401, 1991. |
mouse | LD50 | intraperitoneal | > 8gm/kg (8000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980. |
mouse | LD50 | intravenous | 46500ug/kg (46.5mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980. |
mouse | LD50 | oral | > 8gm/kg (8000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982. | |
mouse | LD50 | subcutaneous | > 8gm/kg (8000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980. |
rat | LD50 | intraperitoneal | 61200ug/kg (61.2mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982. | |
rat | LD50 | intravenous | 41700ug/kg (41.7mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980. |
rat | LD50 | oral | 5243mg/kg (5243mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980. |
rat | LD50 | rectal | > 250mg/kg (250mg/kg) | Yakkyoku. Pharmacy. Vol. 35, Pg. 625, 1984. | |
rat | LD50 | subcutaneous | > 8gm/kg (8000mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980. |
women | TDLo | intravenous | 600ug/kg/1D (0.6mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Lancet. Vol. 2, Pg. 385, 1985. |
women | TDLo | intravenous | 1mg/kg (1mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | British Medical Journal. Vol. 289, Pg. 1579, 1984. |
women | TDLo | rectal | 7200ug/kg/30H (7.2mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Journal of Pediatrics. Vol. 105, Pg. 852, 1984. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 242.5 | deg C | EXP | |
pKa Dissociation Constant | 7.9 | (none) | EXP | |
log P (octanol-water) | 3.9 | (none) | EXP | |
Water Solubility | 0.986 | mg/L | 25 | EST |
Vapor Pressure | 1.15E-14 | mm Hg | 25 | EST |
Henry's Law Constant | 6.11E-22 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.57E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.