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Substance Name: Quipazine maleate [USAN]
RN: 5786-68-5
UNII: JY444CK9IG
InChIKey: QYJJDHZHSCTBII-BTJKTKAUSA-N

Note

  • A pharmacologic congener of serotonin that contracts smooth muscle and has actions similar to those of tricyclic antidepressants. It has been proposed as an oxytocic.

Molecular Formula

  • C13-H15-N3.C4-H4-O4

Molecular Weight

  • 329.354
 

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent
  • Oxytocic
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Names and Synonyms

Name of Substance

  • Quipazine maleate [USAN]

Synonyms

  • 1-(2-Quinolyl)piperazine maleate
  • 2-(1-Piperazinyl)quinoline (Z)-2-butenedioate (1:1)
  • 2-(1-Piperazinyl)quinoline maleate (1:1)
  • EINECS 227-314-2
  • MA 1291
  • Quipazine maleate
  • UNII-JY444CK9IG

Systematic Names

  • 2-(1-Piperazinyl)quinoline maleate
  • Quinoline, 2-(1-piperazinyl)-, (Z)-2-butenedioate (1:1)
  • Quinoline, 2-(1-piperazinyl)-, maleate (1:1)

Registry Numbers

CAS Registry Number

  • 5786-68-5

FDA UNII

  • JY444CK9IG

Related Registry Number

  • 4774-24-7 (Parent)

System Generated Number

  • 0005786685

Molecular Formulas

Molecular Formula

  • C13-H15-N3.C4-H4-O4

Molecular Formula Fragments

  • C13-H15-N3
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C13H15N3.C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

QYJJDHZHSCTBII-BTJKTKAUSA-N

Smiles

c1(N2CCNCC2)nc2c(cccc2)cc1.C(=C/C(O)=O)\C(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 102mg/kg (102mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Farmakologiya i Toksikologiya Vol. 43, Pg. 530, 1980.
mouse LD50 intravenous 75mg/kg (75mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: TREMOR
Farmakologiya i Toksikologiya Vol. 43, Pg. 530, 1980.
mouse LD50 oral 225mg/kg (225mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: TREMOR
Farmakologiya i Toksikologiya Vol. 43, Pg. 530, 1980.