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Substance Name: 2,3-Didemethylcolchicine
RN: 57866-21-4
InChIKey: DEIXKZGDCOFYAR-UHFFFAOYSA-N

Note

  • Blocks amyloid synthesis.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H21-N-O6

Molecular Weight

  • 371.3869
 
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Names and Synonyms

Name of Substance

  • 2,3-Didemethylcolchicine

Synonyms

  • 2,3-Dimethylcolchicine
  • NSC 354974

Systematic Names

  • Acetamide, N-(5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
  • Acetamide, N-(5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethyoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-

Registry Numbers

CAS Registry Number

  • 57866-21-4

System Generated Number

  • 0057866214

Structure Descriptors

InChI

1S/C20H21NO6/c1-10(22)21-14-6-4-11-8-16(24)19(25)20(27-3)18(11)12-5-7-17(26-2)15(23)9-13(12)14/h5,7-9,14,24-25H,4,6H2,1-3H3,(H,21,22)

InChIKey

DEIXKZGDCOFYAR-UHFFFAOYSA-N

Smiles

COC1=CC=C2C(=CC1=O)C(CCc3cc(O)c(O)c(OC)c23)NC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 20mg/kg (20mg/kg)   European Journal of Clinical Investigation. Vol. 22, Pg. 630, 1992.