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Substance Name: Buserelin [INN:BAN]
RN: 57982-77-1
UNII: PXW8U3YXDV
InChIKey: CUWODFFVMXJOKD-UVLQAERKSA-N

Note

  • A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.

Molecular Formula

  • C60-H86-N16-O13

Molecular Weight

  • 1239.4384
 

Classification Codes

  • Drug / Therapeutic Agent
  • Fertility Agents
  • Fertility Agents, Female
  • Hormone
  • Human Data
  • Reproductive Control Agents
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Buserelin [INN:BAN]

Name of Substance

  • Buserelin
  • Buserelin [INN:BAN]

MeSH Heading

  • Buserelin

Synonyms

  • (D-Ser(Bu(sup t)(sup 6)))-LH-RH(1-9)nonapeptide-ethylamide
  • (D-Ser(tbu)(sup 6)-EA(sup 10))-LHRH
  • (D-Ser(tbu)(sup 6)-EA(sup 10))-luteinizing hormone-releasing hormone
  • Buserelin
  • Buserelina
  • Buserelina [INN-Spanish]
  • Busereline
  • Busereline [INN-French]
  • Buserelinum
  • Buserelinum [INN-Latin]
  • CCRIS 2657
  • D-Ser(tbu(sup 6))-LH-RH-(1-9)-nonapeptide ethylamide
  • D-Ser-(TBu)(sup 6)-LHRH-ethylamide
  • EINECS 261-061-9
  • Etilamide
  • HOE 766
  • ICI 123215
  • Luteinizing hormone-releasing hormone, (D-ser(tbu)(sup 6)-EA(sup 10))-
  • S 746766
  • UNII-PXW8U3YXDV

Systematic Names

  • Buserelin
  • Luteinizing hormone-releasing factor (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-
  • Luteinizing hormone-releasing hormone (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-

Registry Numbers

CAS Registry Number

  • 57982-77-1

FDA UNII

  • PXW8U3YXDV

Other Registry Numbers

  • 104428-01-5
  • 111520-35-5

Related Registry Number

  • 68630-75-1 (acetate salt)

System Generated Number

  • 0057982771

Structure Descriptors

InChI

1S/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1

InChIKey

CUWODFFVMXJOKD-UVLQAERKSA-N

Smiles

CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4c3cccc4)NC(=O)[C@H](Cc5cnc[nH]5)NC(=O)[C@@H]6CCC(=O)N6

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TCLo inhalation 1620ug/kg/13W (1.62mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION British Medical Journal. Vol. 294, Pg. 1101, 1987.