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Substance Name: Leucovorin [USAN]
RN: 58-05-9
UNII: Q573I9DVLP
InChIKey: VVIAGPKUTFNRDU-ABLWVSNPSA-N

Note

  • The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

Molecular Formula

  • C20-H23-N7-O7

Molecular Weight

  • 473.4437
 

Classification Codes

  • Antidotes
  • Growth Substances
  • Micronutrients
  • Protective Agents
  • Vitamin B Complex
  • Vitamins

Names and Synonyms

Name of Substance

  • Leucovorin
  • Leucovorin [USAN]

MeSH Heading

  • Leucovorin

Synonyms

  • 10-Formyl-7,8-dihydrofolic acid
  • 5-Formyl-5,6,7,8-tetrahydrofolic acid
  • 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
  • 5-Formyltetrahydrofolic acid
  • Acide folinique
  • CF
  • EINECS 200-361-6
  • Folinate
  • Folinic acid
  • Folinic acid-SF
  • HSDB 6544
  • l-Leucovorin
  • Leucal
  • Leucoverin
  • Leucovorin
  • Leucovorinum (acid)
  • N5-Formyl-5,6,7,8-tetrahydrofolic acid
  • N5-Formyltetrahydrofolic acid
  • UNII-Q573I9DVLP
  • Welcovorin

Systematic Names

  • 5-Formyltetrahydrofolic acid
  • Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L-
  • L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-

Registry Numbers

CAS Registry Number

  • 58-05-9

FDA UNII

  • Q573I9DVLP

Other Registry Numbers

  • 121521-95-7
  • 17435-36-8
  • 3102-53-2
  • 33299-78-4
  • 34786-59-9
  • 40244-99-3
  • 641-41-8

Related Registry Numbers

  • 1492-18-8 (calcium (1:1) salt)
  • 42476-21-1 (mono-hydrochloride salt)
  • 6035-45-6 (calcium (1:1) salt, penta-hydrate)

System Generated Number

  • 0000058059

Structure Descriptors

InChI

InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1

InChIKey

VVIAGPKUTFNRDU-ABLWVSNPSA-N

Smiles

NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N2C=O)N1

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 245 dec deg C   EXP
log P (octanol-water) -4.450 (none)   EST
Atmospheric OH Rate Constant 2.66E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.