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Substance Name: Leucovorin [USAN]
RN: 58-05-9
UNII: Q573I9DVLP
InChIKey: VVIAGPKUTFNRDU-ABLWVSNPSA-N

Note

  • The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid.

Molecular Formula

  • C20-H23-N7-O7

Molecular Weight

  • 473.4437
 

Classification Codes

  • Antidotes
  • Growth Substances
  • Micronutrients
  • Protective Agents
  • Vitamin B Complex
  • Vitamins

Names and Synonyms

Name of Substance

  • Leucovorin
  • Leucovorin [USAN]

MeSH Heading

  • Leucovorin

Synonyms

  • 10-Formyl-7,8-dihydrofolic acid
  • 5-Formyl-5,6,7,8-tetrahydrofolic acid
  • 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
  • 5-Formyltetrahydrofolic acid
  • Acide folinique
  • CF
  • EINECS 200-361-6
  • Folinate
  • Folinic acid
  • Folinic acid-SF
  • HSDB 6544
  • l-Leucovorin
  • Leucal
  • Leucoverin
  • Leucovorin
  • Leucovorinum (acid)
  • N5-Formyl-5,6,7,8-tetrahydrofolic acid
  • N5-Formyltetrahydrofolic acid
  • UNII-Q573I9DVLP
  • Welcovorin

Systematic Names

  • 5-Formyltetrahydrofolic acid
  • Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L-
  • L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-

Registry Numbers

CAS Registry Number

  • 58-05-9

FDA UNII

  • Q573I9DVLP

Other Registry Numbers

  • 121521-95-7
  • 17435-36-8
  • 3102-53-2
  • 33299-78-4
  • 34786-59-9
  • 40244-99-3
  • 641-41-8

Related Registry Numbers

  • 1492-18-8 (calcium (1:1) salt)
  • 42476-21-1 (mono-hydrochloride salt)
  • 6035-45-6 (calcium (1:1) salt, penta-hydrate)

System Generated Number

  • 0000058059

Structure Descriptors

InChI

1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1

InChIKey

VVIAGPKUTFNRDU-ABLWVSNPSA-N

Smiles

c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2CNc3c(c(=O)nc([nH]3)N)N2C=O

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 245 dec deg C   EXP
log P (octanol-water) -4.450 (none)   EST
Atmospheric OH Rate Constant 2.66E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.