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Substance Name: Menadione [USP:BAN]
RN: 58-27-5
UNII: 723JX6CXY5
InChIKey: MJVAVZPDRWSRRC-UHFFFAOYSA-N
Note
- A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Molecular Formula
- C11-H8-O2
Molecular Weight
- 172.182
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- Registry Numbers
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- Toxicity
- Physical Properties
Classification Codes
- Antifibrinolytic Agents
- Coagulants
- Drug / Therapeutic Agent
- Fibrin Modulating Agents
- Growth Substances
- Hematologic Agents
- Hemostatics
- Micronutrients
- Mutation Data
- Reproductive Effect
- Tumor Data
- Vitamin (Prothrombogenic)
- Vitamins
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Names and Synonyms
Name of Substance
- 1,4-Naphthalenedione, 2-methyl-
- Menadione
- Menadione [USP:BAN]
- Vitamin K3
MeSH Heading
- Vitamin K 3
Synonyms
- 1,4-Naphthalenedione, 2-methyl-
- 1,4-Naphthoquinone, 2-methyl-
- 2-Methyl-1,4-naftochinon
- 2-Methyl-1,4-naftochinon [Czech]
- 2-Methyl-1,4-naphthalenedione
- 2-Methyl-1,4-naphthochinon
- 2-Methyl-1,4-naphthochinon [German]
- 2-Methyl-1,4-naphthoquinone
- 2-Methylnaphthoquinone
- 3-Methyl-1,4-naphthoquinone
- AI3-14700
- Aquakay
- Aquinone
- CCRIS 6672
- EINECS 200-372-6
- Hemodal
- HSDB 3354
- Juva-K
- K-Thrombyl
- K-Vitan
- Kaergona
- Kanone
- Kappaxan
- Kappaxan (VAN)
- Kappaxin
- Karcon
- Kareon
- Kativ-G
- Kayklot
- Kaykot
- Kayquinone
- Kipca
- Kipca-oil soluble
- Klottone
- Koaxin
- Kolklot
- Memodol
- Menadion
- Menadione
- Menadionum
- Menaphthon
- Menaphthone
- Menaquinone
- Menaquinone 0
- Mitenon
- Mitenone
- MNQ
- NSC 4170
- Panosine
- Prokayvit
- Synkay
- Thyloquinone
- UNII-723JX6CXY5
- USAF EK-5185
- Vitamin K0
- Vitamin K2(0)
- Vitamin K3
Systematic Names
- 1,4-Naphthalenedione, 2-methyl-
- 1,4-Naphthoquinone, 2-methyl-
- Menadione
Superlist Name
- Menadione
Registry Numbers
CAS Registry Number
- 58-27-5
FDA UNII
- 723JX6CXY5
System Generated Number
- 0000058275
Structure Descriptors
InChI
InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3InChIKey
MJVAVZPDRWSRRC-UHFFFAOYSA-NSmiles
CC1=CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LDLo | intraperitoneal | 100mg/kg (100mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 125, 1940. | |
mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | National Technical Information Service. Vol. AD691-490, | |
mouse | LD50 | oral | 500mg/kg (500mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 125, 1940. | |
mouse | LD50 | subcutaneous | 138mg/kg (138mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 111, 1942. | |
rabbit | LDLo | oral | 230mg/kg (230mg/kg) | VASCULAR: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 111, 1942. |
rat | LD50 | intraperitoneal | 75mg/kg (75mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 107 | deg C | EXP | |
log P (octanol-water) | 2.2 | (none) | EXP | |
Water Solubility | 160 | mg/L | 30 | EXP |
Vapor Pressure | 1.88E-04 | mm Hg | 25 | EST |
Henry's Law Constant | 3.09E-09 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.15E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.