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Substance Name: Dipyridamole [USAN:USP:INN:BAN:JAN]
RN: 58-32-2
UNII: 64ALC7F90C
InChIKey: IZEKFCXSFNUWAM-UHFFFAOYSA-N
Note
- A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Molecular Formula
- C24-H40-N8-O4
Molecular Weight
- 504.632
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- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antiviral (COVID-19)
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Hematologic Agents
- Human Data
- Mutation Data
- Phosphodiesterase Inhibitors
- Platelet Aggregation Inhibitors
- Vasodilator (Coronary)
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Dipyridamole
- Dipyridamole [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Dipyridamole
Synonyms
- 2,2',2'',2'''-((4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol
- 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine
- 4-26-00-03840 (Beilstein Handbook Reference)
- Agilease
- Anginal
- Apricor
- BRN 0068373
- Cardioflux
- Cardoxin
- Chilcolan
- Cleridium 150
- Coribon
- Coronarine
- Corosan
- Coroxin
- Curantyl
- Dipiridamol
- Dipiridamol [INN-Spanish]
- Dipyridamine
- Dipyridamol
- Dipyridamole
- Dipyridamolum
- Dipyridamolum [INN-Latin]
- Dipyridan
- Dipyudamine
- EINECS 200-374-7
- Ethanol, 2,2',2',2'''-((4,8-di-1-iperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-
- Gulliostin
- IV Persantine
- Justpertin
- Kurantil
- Natyl
- NSC 515776
- Peridamol
- Permiltin
- Persantin
- Persantine
- Piroan
- Prandiol
- Prandiol 75
- Pyrimido(5,4-d)pyrimidine, 2,6-bis(bis(2-hydroxyethyl)amino)-4,8-dipiperidino-
- RA 8
- RA-8
- Stenocardil
- Stenocardiol
- Stimolcardio
- UNII-64ALC7F90C
- USAF GE-12
Systematic Names
- Dipyridamole
- Ethanol, 2,2',2'',2'''-((4,8-di-1-piperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-
- Ethanol, 2,2',2'',2'''-((4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetra-
Registry Numbers
CAS Registry Number
- 58-32-2
FDA UNII
- 64ALC7F90C
System Generated Number
- 0000058322
Structure Descriptors
InChI
InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2InChIKey
IZEKFCXSFNUWAM-UHFFFAOYSA-NSmiles
OCCN(CCO)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | LDLo | oral | 1429ug/kg (1.429mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION | JAMA, Journal of the American Medical Association. Vol. 257, Pg. 1515, 1987. |
man | TDLo | oral | 1071ug/kg (1.071mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION | JAMA, Journal of the American Medical Association. Vol. 257, Pg. 1515, 1987. |
mouse | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | National Technical Information Service. Vol. AD691-490, | |
mouse | LD50 | intravenous | 85mg/kg (85mg/kg) | Pharmaceutical Chemistry Journal Vol. 30, Pg. 693, 1996. | |
mouse | LD50 | oral | 2150mg/kg (2150mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 915, 1961. | |
mouse | LD50 | subcutaneous | 2700mg/kg (2700mg/kg) | Drugs in Japan Vol. 6, Pg. 330, 1982. | |
rabbit | LD50 | oral | 4250mg/kg (4250mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
rat | LD50 | intraperitoneal | 1260mg/kg (1260mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
rat | LD50 | intravenous | 195mg/kg (195mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 892, 1972. |
rat | LD50 | oral | 8400mg/kg (8400mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: IRRITABILITY | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 892, 1972. |
rat | LD50 | subcutaneous | 1650mg/kg (1650mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 892, 1972. |
women | TDLo | oral | 35mg/kg (35mg/kg) | VASCULAR: SHOCK BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: DYSPNEA | International Journal of Cardiology. Vol. 46, Pg. 75, 1994. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 163 | deg C | EXP | |
log P (octanol-water) | 2.740 | (none) | EST | |
Atmospheric OH Rate Constant | 3.11E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.