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Substance Name: Thiazinamium metilsulfate [INN]
RN: 58-34-4
UNII: IA16WBX317
InChIKey: BVIDQAVCCRUFGU-UHFFFAOYSA-M

Note

  • A quaternary ammonium phenothiazine, usually as the methyl sulfate, that has both histamine 1 and acetylcholine blocking actions.

Molecular Formula

  • C18-H23-N2-S.C-H3-O4-S

Molecular Weight

  • 410.5564
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Thiazinamium
  • Thiazinamium metilsulfate [INN]

Synonyms

  • 3354 R.P.
  • Ammonium, trimethyl(1-methyl-2-phenothiazin-10-ylethyl)-, methyl sulfate
  • EINECS 200-376-8
  • Methylphenazonium methosulfate
  • Methylpromethazinium methylsulfuricum
  • Metilsulfate de thiazinamium
  • Metilsulfate de thiazinamium [INN-French]
  • Metilsulfato de tiazinamio
  • Metilsulfato de tiazinamio [INN-Spanish]
  • Multergan
  • Multezin
  • N,N,N,alpha-Tetramethyl-10H-phenothiazine-10-ethanaminium methyl sulfate
  • N-(beta-(10-Phenothiazinyl)propyl)trimethylammonium methyl sulfate
  • Padisal
  • Prothazin methosulfate
  • RP 3554
  • Thiazinamii metilsulfas
  • Thiazinamii metilsulfas [INN-Latin]
  • Thiazinamium methyl sulfate
  • Thiazinamium methylsulfate
  • Thiazinamium metilsulfate
  • Trimethyl (1-methyl-2-phenothiazin-10-ylethyl)ammonium methyl sulfate
  • Trimethyl(1-methyl-2-(10-phenothiazinyl)ethyl)ammonium methyl sulfate
  • UNII-IA16WBX317
  • Valan

Systematic Names

  • 10H-Phenothiazine-10-ethanaminium, N,N,N,alpha-tetramethyl-, methyl sulfate
  • Thiazinamium metilsulfate
  • Trimethyl(1-methyl-2-phenothiazin-10-ylethyl)ammonium methyl sulfate

Registry Numbers

CAS Registry Number

  • 58-34-4

FDA UNII

  • IA16WBX317

Other Registry Numbers

  • 28137-55-5
  • 67078-89-1

System Generated Number

  • 0000058344

Molecular Formulas

Molecular Formula

  • C18-H23-N2-S.C-H3-O4-S

Molecular Formula Fragments

  • C-H3-O4-S
  • C18-H23-N2-S
  • COMPONENT

Structure Descriptors

InChI

1S/C18H23N2S.CH4O4S/c1-14(20(2,3)4)13-19-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)19;1-5-6(2,3)4/h5-12,14H,13H2,1-4H3;1H3,(H,2,3,4)/q+1;/p-1

InChIKey

BVIDQAVCCRUFGU-UHFFFAOYSA-M

Smiles

CC(CN1c2ccccc2Sc3c1cccc3)[N+](C)(C)C.COS(=O)(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 75mg/kg (75mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 171, 1954.
mouse LD50 intravenous 5mg/kg (5mg/kg)   Pharmazie. Vol. 19, Pg. 762, 1964.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 208 deg C   EXP
log P (octanol-water) 2.660 (none)   EST
Water Solubility 1.00E+05 mg/L 25 EXP
Atmospheric OH Rate Constant 2.17E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.