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Substance Name: Perphenazine [USP:INN:BAN:JAN]
RN: 58-39-9
UNII: FTA7XXY4EZ
InChIKey: RGCVKNLCSQQDEP-UHFFFAOYSA-N
Note
- An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
Molecular Formula
- C21-H26-Cl-N3-O-S
Molecular Weight
- 403.9754
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antipsychotic
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Tranquilizing Agents
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Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Perphenazine
- Perphenazine [USP:INN:BAN:JAN]
MeSH Heading
- Perphenazine
Synonyms
- 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina
- 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina [Italian]
- 1-(2-Hydroxyethyl)-4-(3-(2-chloro-10-phenothiazinyl)propyl)piperazine
- 1-Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-
- 1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-
- 2-Chloro-10-(3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine
- 2-Chloro-10-3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl phenothiazine
- 4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol
- AI3-50151
- Chlorperphenazine
- Chlorpiprazine
- Decentan
- EINECS 200-381-5
- Emesinal
- Etaperazin
- Etaperazine
- Ethaperazine
- F-mon
- Fentazin
- gamma-(4-(beta-Hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine
- HSDB 3379
- NSC 150866
- Perfenazina
- Perfenazina [INN-Spanish]
- Perfenazina [Italian]
- Perfenazine
- Perphenan
- Perphenazin
- Perphenazine
- Perphenazinum
- Perphenazinum [INN-Latin]
- Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-
- PZC
- Sch 3940
- Thilatazin
- Tranquisan
- Trifaron
- Trilafon
- Trilifan
- Triphenot
- UNII-FTA7XXY4EZ
Systematic Names
- 1-Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-
- 1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-
- Perphenazine
- Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-
Mixture Names
- Etrafon
- Triavil
Registry Numbers
CAS Registry Number
- 58-39-9
FDA UNII
- FTA7XXY4EZ
System Generated Number
- 0000058399
Structure Descriptors
InChI
InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2InChIKey
RGCVKNLCSQQDEP-UHFFFAOYSA-NSmiles
OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 32mg/kg (32mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
cat | LD50 | intravenous | 35mg/kg (35mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 638, 1960. |
cat | LD50 | subcutaneous | > 2500ug/kg (2.5mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. | |
cat | LDLo | oral | 1gm/kg (1000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 638, 1960. |
dog | LD50 | intravenous | 51mg/kg (51mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY | Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 638, 1960. |
dog | LD50 | subcutaneous | > 20mg/kg (20mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. | |
human | TDLo | intramuscular | 71428ng/kg (0.071428mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | British Medical Journal. Vol. 3, Pg. 867, 1967. |
monkey | LD50 | subcutaneous | > 510ug/kg (0.51mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. | |
mouse | LD50 | intraperitoneal | 64mg/kg (64mg/kg) | Journal of Pharmaceutical Sciences. Vol. 59, Pg. 976, 1970. | |
mouse | LD50 | intravenous | 19mg/kg (19mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. |
mouse | LD50 | oral | 120mg/kg (120mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 185, 1973. | |
mouse | LD50 | subcutaneous | > 80mg/kg (80mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. |
pigeon | LD50 | intramuscular | 250mg/kg (250mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 638, 1960. |
pigeon | LD50 | intravenous | 32mg/kg (32mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE | Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 638, 1960. |
rat | LD50 | intraperitoneal | 146mg/kg (146mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 917, 1974. | |
rat | LD50 | intravenous | 34mg/kg (34mg/kg) | Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971. | |
rat | LD50 | oral | 318mg/kg (318mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
rat | LD50 | subcutaneous | > 80mg/kg (80mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 97 | deg C | EXP | |
pKa Dissociation Constant | 7.94 | (none) | EXP | |
log P (octanol-water) | 4.2 | (none) | EXP | |
Water Solubility | 28.3 | mg/L | 24 | EXP |
Vapor Pressure | 2.84E-13 | mm Hg | 25 | EST |
Henry's Law Constant | 5.19E-18 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.66E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.