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Substance Name: Promazine [INN:BAN]
RN: 58-40-2
UNII: O9M39HTM5W
InChIKey: ZGUGWUXLJSTTMA-UHFFFAOYSA-N

Note

  • A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Molecular Formula

  • C17-H20-N2-S

Molecular Weight

  • 284.425
 

Classification Codes

  • Antiemetics
  • Antipsychotic Agents
  • Autonomic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Mutation Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Names and Synonyms

Results Name

  • Promazine [INN:BAN]

Name of Substance

  • Promazine
  • Promazine [INN:BAN]

MeSH Heading

  • Promazine

Synonyms

  • 10-(3-(Dimethylamino)propyl)phenothiazine
  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-
  • 3276 R. P.
  • A 145
  • Ampazine
  • Berophen
  • EINECS 200-382-0
  • Esparin
  • HSDB 3172
  • Liranol
  • N-(3-Dimethylaminopropyl)phenothiazine
  • N-Dimethylamino-1-methylethyl thiodiphenylamine
  • Neo-Hibernex
  • NSC 31447
  • Prazin
  • Prazine
  • Promazin
  • Promazina
  • Promazina [INN-Spanish]
  • Promazina [Italian]
  • Promazine
  • Promazinum
  • Promazinum [INN-Latin]
  • Promwill
  • Propazinum
  • Protactyl
  • Romtiazin
  • RP 3276
  • Sinophenin
  • Tomil
  • UNII-O9M39HTM5W
  • Verophen
  • WY 1094

Systematic Names

  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl- (9CI)
  • Phenothiazine, 10-(3-(dimethylamino)propyl)-
  • Promazine

Registry Numbers

CAS Registry Number

  • 58-40-2

FDA UNII

  • O9M39HTM5W

System Generated Number

  • 0000058402

Structure Descriptors

InChI

1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3

InChIKey

ZGUGWUXLJSTTMA-UHFFFAOYSA-N

Smiles

CN(C)CCCN1c2ccccc2Sc3c1cccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 140mg/kg (140mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 69, 1965.
mouse LD50 intravenous 45mg/kg (45mg/kg) BEHAVIORAL: SLEEP Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 87, 1962.
mouse LD50 oral 401mg/kg (401mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 489, 1958.
mouse LD50 subcutaneous 110mg/kg (110mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974.
rabbit LD50 intravenous 21mg/kg (21mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat LD50 intravenous 14500ug/kg (14.5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: CHANGES IN CIRCULATION: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 119, Pg. 311, 1959.
rat LD50 oral 350mg/kg (350mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 507, 1958.
rat LD50 subcutaneous 192mg/kg (192mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974.
rat LDLo intraperitoneal 210mg/kg (210mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
pKa Dissociation Constant 9.36 (none)   EXP
log P (octanol-water) 4.55 (none)   EXP
Water Solubility 14.2 mg/L 24 EXP
Vapor Pressure 7.89E-07 mm Hg 25 EST
Henry's Law Constant 4.98E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.71E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.