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Substance Name: Pyridoxine hydrochloride [USP:JAN]
RN: 58-56-0
UNII: 68Y4CF58BV
InChIKey: ZUFQODAHGAHPFQ-UHFFFAOYSA-N

Notes

  • The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
  • VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.

Molecular Formula

  • C8-H11-N-O3.Cl-H

Molecular Weight

  • 205.6398
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Vitamin (Enzyme Co-Factor)

Names and Synonyms

Name of Substance

  • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
  • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
  • Pyridoxine hydrochloride
  • Pyridoxine hydrochloride [USP:JAN]
  • Vitamin B6 hydrochloride

Synonyms

  • 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride
  • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
  • 3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
  • 3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride
  • 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
  • 4,5-Bis(hydroxymethyl)-3-hydroxy-2-methylpyridine hydrochloride
  • 5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
  • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
  • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride
  • Aderomine hydrochloride
  • Aderoxin
  • Aderoxine
  • AI3-19016
  • Alestrol
  • Becilan
  • Beesix
  • Benadon
  • Bonadoxin
  • Bonasanit
  • Campoviton 6
  • CCRIS 1903
  • Clorhidrato de piridoxina
  • EINECS 200-386-2
  • Godabion
  • Gravidox
  • Hexa-Betalin
  • Hexa-Betalin (R)
  • Hexabione hydrochloride
  • Hexavibex
  • Hexermin
  • Hexobion
  • HSDB 1212
  • Hydoxin
  • NSC 36225
  • Paxadon
  • Pydox
  • Pyridipca
  • Pyridox
  • Pyridoxin hydrochloride
  • Pyridoxine chloride
  • Pyridoxine HCl
  • Pyridoxine hydrochloride
  • Pyridoxine monohydrochloride
  • Pyridoxinium chloride
  • Pyridoxinum hydrochloricum
  • Pyridoxinum hydrochloricum (Hungarian)
  • Pyridoxol hydrochloride
  • Rodex
  • Rodex (R)
  • UNII-68Y4CF58BV
  • VibeX
  • Vitamin B6 hydrochloride

Systematic Names

  • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
  • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1)
  • Pyridoxine hydrochloride
  • Pyridoxol, hydrochloride

Superlist Names

  • 3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
  • Pyridoxine hydrochloride

Mixture Names

  • Bendectin
  • Spondylonal

Registry Numbers

CAS Registry Number

  • 58-56-0

FDA UNII

  • 68Y4CF58BV

Related Registry Number

  • 65-23-6 (Parent)

System Generated Number

  • 0000058560

Molecular Formulas

Molecular Formula

  • C8-H11-N-O3.Cl-H

Molecular Formula Fragments

  • C8-H11-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChIKey

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

Smiles

Cc1c(c(c(cn1)CO)CO)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intramuscular 500mg/kg (500mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
cat LD50 intravenous 560mg/kg (560mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
cat LD50 oral 1gm/kg (1000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
dog LD50 oral > 500mg/kg (500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
mouse LD50 intravenous 660mg/kg (660mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
mouse LD50 oral 5500mg/kg (5500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
mouse LD50 subcutaneous 2450mg/kg (2450mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
pigeon LD50 intravenous 145mg/kg (145mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rabbit LD50 intravenous 464mg/kg (464mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rat LD50 intravenous 530mg/kg (530mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rat LD50 oral 4gm/kg (4000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rat LD50 subcutaneous 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 207 deg C   EXP
log P (octanol-water) -4.320 (none)   EST
Water Solubility 2.20E+05 mg/L   EXP
Vapor Pressure 6.41E-08 mm Hg 25 EST
Henry's Law Constant 1.32E-21 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.06E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.