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Substance Name: Puromycin aminonucleoside
RN: 58-60-6
UNII: 0Q580U88V8
InChIKey: RYSMHWILUNYBFW-GRIPGOBMSA-N

Note

  • PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineoplastic properties and can cause nephrosis.

Molecular Formula

  • C12-H18-N6-O3

Molecular Weight

  • 294.313
 

Classification Codes

  • Antibiotics, Antineoplastic
  • Antimetabolites
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Mutation Data
  • Noxae
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Puromycin aminonucleoside

MeSH Heading

  • Puromycin aminonucleoside

Synonyms

  • 3'-Amino-3'-deoxy-N6,N6-dimethyladenosine
  • 4-26-00-03697 (Beilstein Handbook Reference)
  • 6-Dimethylamino-9-(3'-ribosylamine)purine
  • Aminonucleoside
  • Aminonucleoside puromycin
  • ARDMA
  • BRN 0093902
  • EINECS 200-388-3
  • NSC 3056
  • Puromycin aminonucleoside
  • SAN
  • Stylomycin aminonucleoside
  • UNII-0Q580U88V8

Systematic Names

  • 3'-Amino-3'-deoxy-N,N-dimethyladenosine
  • Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl-

Registry Numbers

CAS Registry Number

  • 58-60-6

FDA UNII

  • 0Q580U88V8

Other Registry Numbers

  • 136680-68-7
  • 28315-29-9
  • 54833-68-0

System Generated Number

  • 0000058606

Structure Descriptors

InChI

1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1

InChIKey

RYSMHWILUNYBFW-GRIPGOBMSA-N

Smiles

n1(c2c(c(ncn2)N(C)C)nc1)[C@@H]1O[C@H](CO)[C@H]([C@H]1O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD intravenous > 50mg/kg (50mg/kg) KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Journal of Toxicological Sciences. Vol. 22, Pg. 343, 1997.
rat LD subcutaneous > 150mg/kg (150mg/kg) KIDNEY, URETER, AND BLADDER: PROTEINURIS Revista de Investigacion Clinica. Vol. 42, Pg. 29, 1990.