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Substance Name: Adenosine [USAN:USP:BAN]
RN: 58-61-7
UNII: K72T3FS567
InChIKey: OIRDTQYFTABQOQ-KQYNXXCUSA-N
Note
- A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Molecular Formula
- C10-H13-N5-O4
Molecular Weight
- 267.2437
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesics
- Anti-Arrhythmia Agents
- Antiviral (COVID-19)
- Cardiac Depressant (Anti-Arrhythmic)
- Cardiovascular Agents
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Purinergic Agonists
- Purinergic P1 Receptor Agonists
- Sensory System Agents
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Adenosine
- Adenosine [USAN:USP:BAN]
MeSH Heading
- Adenosine
Synonyms
- 6-Amino-9-beta-D-ribofuranosyl-9H-purine
- 6-Amino-9beta-D-ribofuranosyl-9H-purine
- 9-beta-D-Ribofuranosidoadenine
- 9-beta-D-Ribofuranosyl-9H-purin-6-amine
- 9-beta-D-Ribofuranosyladenine
- 9beta-D-Ribofuranosyladenine
- 9H-Purin-6-amine, 9beta-D-ribofuranosyl-
- Adenine nucleoside
- Adenine riboside
- Adenocard
- Adenoscan
- Adenosin
- Adenosin [German]
- Adenosine
- AI3-52413
- beta-Adenosine
- beta-D-Adenosine
- beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-
- beta-D-Ribofuranoside, adenine-9
- Boniton
- Caswell No. 010B
- CCRIS 2557
- EINECS 200-389-9
- HSDB 7774
- Myocol
- NSC 627048
- NSC 7652
- Nucleocardyl
- Sandesin
- SR 96225
- UNII-K72T3FS567
- USAF CB-10
Systematic Name
- Adenosine
Registry Numbers
CAS Registry Number
- 58-61-7
FDA UNII
- K72T3FS567
Other Registry Numbers
- 46946-45-6
- 46969-16-8
System Generated Number
- 0000058617
Structure Descriptors
InChI
InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1InChIKey
OIRDTQYFTABQOQ-KQYNXXCUSA-NSmiles
Nc1ncnc2c1ncn2[C@@H]3O[C@H](CO)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | intravenous | 50ug/kg/1M-I (0.05mg/kg) | LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION | Human & Experimental Toxicology. Vol. 13, Pg. 263, 1994. |
man | TDLo | intravenous | 143ug/kg/I (0.143mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: HEADACHE | Medical Journal of Australia. |
man | TDLo | intravenous | 171ug/kg (0.171mg/kg) | CARDIAC: PULSE RATE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA | American Journal of Emergency Medicine. Vol. 11, Pg. 192, 1993. |
man | TDLo | intravenous | 257ug/kg (0.257mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: CYANOSIS | American Journal of Emergency Medicine. Vol. 11, Pg. 249, 1993. |
man | TDLo | intravenous | 257ug/kg/1D-I (0.257mg/kg) | CARDIAC: CHANGE IN RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Annals of Internal Medicine. Vol. 122, Pg. 351, 1995. |
mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | National Technical Information Service. Vol. AD277-689, | |
mouse | LD50 | oral | > 20gm/kg (20000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 45, 1980. | |
women | TDLo | intravenous | 240ug/kg (0.24mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | American Journal of Emergency Medicine. Vol. 14, Pg. 300, 1996. |
women | TDLo | intravenous | 360ug/kg/1H-I (0.36mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: CHANGE IN RATE | American Journal of Emergency Medicine. Vol. 10, Pg. 326, 1992. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 235.5 | deg C | EXP | |
log P (octanol-water) | -1.05E+00 | (none) | EXP | |
Water Solubility | 8230 | mg/L | 25 | EST |
Vapor Pressure | 7.00E-15 | mm Hg | 25 | EST |
Henry's Law Constant | 1.11E-22 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.38E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.