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Substance Name: Inosine [INN:JAN]
RN: 58-63-9
UNII: 5A614L51CT
InChIKey: UGQMRVRMYYASKQ-KQYNXXCUSA-N

Note

  • A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)

Molecular Formula

  • C10-H12-N4-O5

Molecular Weight

  • 268.2278
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Inosine
  • Inosine [INN:JAN]

MeSH Heading

  • Inosine

Synonyms

  • 9-beta-D-Ribofuranosylhypoxanthine
  • AI3-52241
  • Atorel
  • beta-D-Ribofuranoside, hypoxanthine-9
  • beta-Inosine
  • EINECS 200-390-4
  • HXR
  • Hypoxanthine D-riboside
  • Hypoxanthine nucleoside
  • Hypoxanthine ribonucleoside
  • Hypoxanthine riboside
  • Hypoxanthine, 9-beta-D-ribofuranosyl-
  • Hypoxanthosine
  • INO
  • INO 495
  • Inosina
  • Inosina [INN-Spanish]
  • Inosine
  • Inosinum
  • Inosinum [INN-Latin]
  • NSC 20262
  • Oxiamin
  • Panholic-L
  • Pantholic-L
  • Ribonosine
  • Selfer
  • Trophicardyl
  • UNII-5A614L51CT

Systematic Name

  • Inosine

Registry Numbers

CAS Registry Number

  • 58-63-9

FDA UNII

  • 5A614L51CT

Other Registry Numbers

  • 12712-98-0
  • 132953-54-9
  • 28861-88-3
  • 292853-81-7
  • 4181-51-5
  • 691344-25-9
  • 740029-83-8

System Generated Number

  • 0000058639

Structure Descriptors

InChI

InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1

InChIKey

UGQMRVRMYYASKQ-KQYNXXCUSA-N

Smiles

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3C(=O)N=CNc23

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3175mg/kg (3175mg/kg)   Pharmaceutical Chemistry Journal Vol. 20, Pg. 160, 1986.
mouse LD50 intravenous > 2800mg/kg (2800mg/kg)   Drugs in Japan Vol. -, Pg. 156, 1995.
mouse LD50 oral > 20gm/kg (20000mg/kg)   Drugs in Japan Vol. 6, Pg. 77, 1982.
mouse LD50 subcutaneous 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 77, 1982.
rat LD50 intraperitoneal 2900mg/kg (2900mg/kg)   Drugs in Japan Vol. 6, Pg. 77, 1982.
rat LD50 intravenous > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. 77, 1982.
rat LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 156, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 218 dec deg C   EXP
log P (octanol-water) -2.10E+00 (none)   EXP
Water Solubility 1.58E+04 mg/L 20 EXP
Vapor Pressure 1.40E-14 mm Hg 25 EST
Henry's Law Constant 3.28E-23 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.78E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.