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Substance Name: Lindane [USAN:USP:INN:BAN]
RN: 58-89-9
UNII: 59NEE7PCAB
InChIKey: JLYXXMFPNIAWKQ-GNIYUCBRSA-N
Note
- An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.
Molecular Formula
- C6-H6-Cl6
Molecular Weight
- 290.8314
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Agricultural Chemical
- Drug / Therapeutic Agent
- Fungicide, Bactericide, Wood Preservative
- Human Data
- Insecticide
- Insecticides
- Mutation Data
- Pediculicide
- Pesticides
- Reproductive Effect
- Scabicide
- Tumor Data
Superlist Classification Codes
- 2007 CERCLA Priority List, Rank: 32
- 2011 CERCLA Priority List, Rank: 34
- Reasonably Anticipated to be a Carcinogen
- Reportable Quantity (RQ) = 1 lb
- Threshold Planning Quantity (TPQ) = 1000/10000 lb
- TWA 0.5 mg/m3; skin
- TWA 0.5 mg/m3; skin; Confirmed animal carcinogen with unknown relevance to humans
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Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Lindane
- Lindane [USAN:USP:INN:BAN]
MeSH Heading
- Hexachlorocyclohexane
Synonyms
- 1,2,3,4,5,6-Hexachlorocyclohexane, gamma-isomer
- 4-05-00-00058 (Beilstein Handbook Reference)
- Aalindan
- Aficide
- Agrocide
- Agrocide 6G
- Agrocide 7
- Agrocide III
- Agrocide WP
- Agronexit
- AI3-07796
- Ameisenmittel merck
- Ameisentod
- Aparasin
- Aphtiria
- Aplidal
- Arbitex
- Arcotal S
- BBH
- Ben-Hex
- Benhexol
- Bentox 10
- Benzene hexachloride (Ambiguous)
- Benzene hexachloride-gamma isomer
- Benzene-1,2,3,4,5,6-hexachloride (Ambiguous)
- Bexol
- BHC (insecticide)
- BRN 1907337
- Caswell No. 079
- Caswell No. 527
- CCRIS 329
- Celanex
- Chloresene
- Codechine
- Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-
- Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer
- Detmol Extract
- Detox 25
- Devoran
- Dol Granule
- Drilltox-Spezial Aglukon
- EINECS 200-401-2
- ENT 7,796
- Entomoxan
- EPA Pesticide Chemical Code 009001
- Fenoform forte
- Forst-Nexen
- Gallogama
- Gamacarbatox
- Gamacid
- Gamacide
- Gamacide 20
- Gamaphex
- Gamene
- Gamiso
- gamma Benzene hexachloride
- gamma-1,2,3,4,5,6-Hexachlorocyclohexane
- gamma-Benzenehexachloride
- gamma-Benzohexachloride
- gamma-HCH
- gamma-Hexachlorcyclohexanum
- gamma-Hexachlorobenzene
- Gamma-mean 400
- Gammalin
- Gammalin 20
- Gammaterr
- Geobilan
- Geolin G 3
- Gexane
- H.C.H.
- HCCH
- HCH
- HCH [BSI]
- Heclotox
- Hexa
- Hexachloran
- Hexachlorane
- Hexachlorocyclohexane
- Hexachlorocyclohexane, gamma-isomer
- Hexaverm
- Hexcidum
- Hexicide
- Hexyclan
- HGI
- Hilbeech
- Hortex
- HSDB 646
- Hungaria L7
- Inexit
- Jacutin
- Kokotine
- Kwell
- Lacco HI lin
- Lasochron
- Latka 666
- Latka 666 [Czech]
- Lendine
- Lentox
- Lidenal
- Lindafor
- Lindagam
- Lindagrain
- Lindagranox
- Lindane
- Lindano
- Lindano [INN-Spanish]
- Lindanum
- Lindanum [INN-Latin]
- Lindapoudre
- Lindatox
- Lindex
- Lindosep
- Lintox
- Linvur
- Lorexane
- Mglawik L
- Milbol 49
- Mszycol
- NCI-C00204
- Neo-Scabicidol
- Nexen FB
- Nexit
- Nexit-stark
- Nexol-E
- Nicochloran
- Novigam
- Omnitox
- Ovadziak
- Owadziak
- Pedraczak
- Pflanzol
- PLK
- Quellada
- RCRA waste number U129
- Sang gamma
- Scabene
- Silvanol
- Spritz-Rapidin
- Spritzlindane
- Spruehpflanzol
- Streunex
- TAP 85
- Tri-6
- UNII-59NEE7PCAB
- Verindal Ultra
- Viton
Systematic Names
- Cyclohexane, 1,2,3,4,5,6-hexachloro-, (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-
- Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer
- gamma-HCH or gamma-BHC
- gamma-Hexachlorocyclohexane
Superlist Names
- 1,2,3,4,5,6-Hexachlorocyclohexane (all stereo isomers, including lindane)
- Cyclohexane, 1,2,3,4,5,6-hexachloro-, (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-
- gamma-BHC
- gamma-HCH [Hexachlorocyclohexanes]
- gamma-Hexachlorocyclohexane [Lindane and other hexachlorocyclohexane isomers]
- HCH, technical grade
- HCH, technical grade [Hexachlorocyclohexanes]
- Hexachlorocyclohexane, gamma isomer
- Hexachlorocyclohexane, gamma-
- Lindane
- Lindane [Hexachlorocyclohexanes]
- RCRA waste no. U129
Mixture Name
- Kwell
Registry Numbers
CAS Registry Number
- 58-89-9
FDA UNII
- 59NEE7PCAB
Other Registry Numbers
- 25897-48-7
- 53529-37-6
- 55963-79-6
- 8007-42-9
- 8073-23-2
System Generated Number
- 0000058899
Structure Descriptors
InChI
InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+InChIKey
JLYXXMFPNIAWKQ-GNIYUCBRSA-NSmiles
Cl[C@@H]1[C@H](Cl)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | oral | 25mg/kg (25mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 72, 1982. | |
| cat | LDLo | unreported | 50mg/kg (50mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Pharmacology and Toxicology. English translation of FATOAO. Vol. 22, Pg. 273, 1959. |
| child | TDLo | oral | 111mg/kg (111mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Environmental Health. Vol. 25, Pg. 374, 1972. |
| child | TDLo | oral | 180mg/kg (180mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956. |
| dog | LD50 | oral | 40mg/kg (40mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 11, 1978. | |
| dog | LDLo | intravenous | 7500ug/kg (7.5mg/kg) | Tieraerztliche Umschau. Vol. 5, Pg. 61, 1950. | |
| guinea pig | LD50 | oral | 127mg/kg (127mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 386, 1947. | |
| hamster | LD50 | intraperitoneal | 640mg/kg (640mg/kg) | Archives of Toxicology. Vol. 58, Pg. 152, 1986. | |
| hamster | LD50 | oral | 360mg/kg (360mg/kg) | European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974. | |
| human | LDLo | oral | 840mg/kg (840mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 1232, 1992. | |
| mammal (species unspecified) | LD50 | unreported | 300mg/kg (300mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(3), Pg. 32, 1973. | |
| man | TDLo | skin | 20mg/kg/6W-I (20mg/kg) | SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE CARDIAC: OTHER CHANGES | American Journal of Diseases of Children. Vol. 141, Pg. 125, 1987. |
| mouse | LCLo | inhalation | 120mg/m3/6H (120mg/m3) | BLOOD: CHANGES IN OTHER CELL COUNT (UNSPECIFIED) BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 8(10), Pg. 55, 1964. |
| mouse | LD50 | intracrebral | 60mg/kg (60mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Toxicology Letters. Vol. 60, Pg. 289, 1992. |
| mouse | LD50 | intraperitoneal | 125mg/kg (125mg/kg) | Soviet Genetics. English translation of GNKAA5. Vol. 2, Pg. 80, 1966. | |
| mouse | LD50 | oral | 44mg/kg (44mg/kg) | Journal of Economic Entomology. Vol. 65, Pg. 632, 1972. | |
| rabbit | LD50 | oral | 60mg/kg (60mg/kg) | Journal of Hygiene, Epidemiology, Microbiology, and Immunology. Vol. 22, Pg. 115, 1978. | |
| rabbit | LD50 | skin | 50mg/kg (50mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Quarterly Bulletin--Association of Food and Drug Officials of the United States. Vol. 16, Pg. 3, 1952. |
| rabbit | LDLo | intravenous | 4500ug/kg (4.5mg/kg) | BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 140, 1948. |
| rat | LD50 | intraperitoneal | 35mg/kg (35mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 212, Pg. 463, 1951. | |
| rat | LD50 | oral | 76mg/kg (76mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 11, 1978. | |
| rat | LD50 | skin | 414mg/kg (414mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(7), Pg. 87, 1990. | |
| rat | LD50 | unreported | 125mg/kg (125mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 28(8), Pg. 29, 1963. | |
| rat | LD50 | unreported | 125mg/kg (125mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 28(8), Pg. 29, 1963. |
| women | TDLo | skin | 19mg/kg/1H-I (19mg/kg) | BEHAVIORAL: EXCITEMENT SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Annals of Emergency Medicine. Vol. 24, Pg. 972, 1994. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 112.5 | deg C | EXP | |
| Boiling Point | 323.4 | deg C | EXP | |
| log P (octanol-water) | 3.72 | (none) | EXP | |
| Water Solubility | 7.3 | mg/L | 25 | EXP |
| Vapor Pressure | 4.20E-05 | mm Hg | 20 | EXP |
| Henry's Law Constant | 5.14E-06 | atm-m3/mole | 25 | EXP |
| Atmospheric OH Rate Constant | 1.90E-13 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.