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Substance Name: Lindane [USAN:USP:INN:BAN]
RN: 58-89-9
UNII: 59NEE7PCAB
InChIKey: JLYXXMFPNIAWKQ-GNIYUCBRSA-N

Note

  • An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.

Molecular Formula

  • C6-H6-Cl6

Molecular Weight

  • 290.8314
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Fungicide, Bactericide, Wood Preservative
  • Human Data
  • Insecticide
  • Insecticides
  • Mutation Data
  • Pediculicide
  • Pesticides
  • Reproductive Effect
  • Scabicide
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 32
  • 2011 CERCLA Priority List, Rank: 34
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 1 lb
  • Threshold Planning Quantity (TPQ) = 1000/10000 lb
  • TWA 0.5 mg/m3; skin
  • TWA 0.5 mg/m3; skin; Confirmed animal carcinogen with unknown relevance to humans

Names and Synonyms

Name of Substance

  • Lindane
  • Lindane [USAN:USP:INN:BAN]

MeSH Heading

  • Lindane

Synonyms

  • 1,2,3,4,5,6-Hexachlorocyclohexane, gamma-isomer
  • 4-05-00-00058 (Beilstein Handbook Reference)
  • Aalindan
  • Aficide
  • Agrocide
  • Agrocide 6G
  • Agrocide 7
  • Agrocide III
  • Agrocide WP
  • Agronexit
  • AI3-07796
  • Ameisenmittel merck
  • Ameisentod
  • Aparasin
  • Aphtiria
  • Aplidal
  • Arbitex
  • Arcotal S
  • BBH
  • Ben-Hex
  • Benhexol
  • Bentox 10
  • Benzene hexachloride (Ambiguous)
  • Benzene hexachloride-gamma isomer
  • Benzene-1,2,3,4,5,6-hexachloride (Ambiguous)
  • Bexol
  • BHC (insecticide)
  • BRN 1907337
  • Caswell No. 079
  • Caswell No. 527
  • CCRIS 329
  • Celanex
  • Chloresene
  • Codechine
  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-
  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer
  • Detmol Extract
  • Detox 25
  • Devoran
  • Dol Granule
  • Drilltox-Spezial Aglukon
  • EINECS 200-401-2
  • ENT 7,796
  • Entomoxan
  • EPA Pesticide Chemical Code 009001
  • Fenoform forte
  • Forst-Nexen
  • Gallogama
  • Gamacarbatox
  • Gamacid
  • Gamacide
  • Gamacide 20
  • Gamaphex
  • Gamene
  • Gamiso
  • gamma Benzene hexachloride
  • gamma-1,2,3,4,5,6-Hexachlorocyclohexane
  • gamma-Benzenehexachloride
  • gamma-Benzohexachloride
  • gamma-HCH
  • gamma-Hexachlorcyclohexanum
  • gamma-Hexachlorobenzene
  • Gamma-mean 400
  • Gammalin
  • Gammalin 20
  • Gammaterr
  • Geobilan
  • Geolin G 3
  • Gexane
  • H.C.H.
  • HCCH
  • HCH
  • HCH [BSI]
  • Heclotox
  • Hexa
  • Hexachloran
  • Hexachlorane
  • Hexachlorocyclohexane
  • Hexachlorocyclohexane, gamma-isomer
  • Hexaverm
  • Hexcidum
  • Hexicide
  • Hexyclan
  • HGI
  • Hilbeech
  • Hortex
  • HSDB 646
  • Hungaria L7
  • Inexit
  • Jacutin
  • Kokotine
  • Kwell
  • Lacco HI lin
  • Lasochron
  • Latka 666
  • Latka 666 [Czech]
  • Lendine
  • Lentox
  • Lidenal
  • Lindafor
  • Lindagam
  • Lindagrain
  • Lindagranox
  • Lindane
  • Lindano
  • Lindano [INN-Spanish]
  • Lindanum
  • Lindanum [INN-Latin]
  • Lindapoudre
  • Lindatox
  • Lindex
  • Lindosep
  • Lintox
  • Linvur
  • Lorexane
  • Mglawik L
  • Milbol 49
  • Mszycol
  • NCI-C00204
  • Neo-Scabicidol
  • Nexen FB
  • Nexit
  • Nexit-stark
  • Nexol-E
  • Nicochloran
  • Novigam
  • Omnitox
  • Ovadziak
  • Owadziak
  • Pedraczak
  • Pflanzol
  • PLK
  • Quellada
  • RCRA waste number U129
  • Sang gamma
  • Scabene
  • Silvanol
  • Spritz-Rapidin
  • Spritzlindane
  • Spruehpflanzol
  • Streunex
  • TAP 85
  • Tri-6
  • UNII-59NEE7PCAB
  • Verindal Ultra
  • Viton

Systematic Names

  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-
  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer
  • gamma-HCH or gamma-BHC
  • gamma-Hexachlorocyclohexane

Superlist Names

  • 1,2,3,4,5,6-Hexachlorocyclohexane (all stereo isomers, including lindane)
  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-
  • gamma-BHC
  • gamma-HCH [Hexachlorocyclohexanes]
  • gamma-Hexachlorocyclohexane [Lindane and other hexachlorocyclohexane isomers]
  • HCH, technical grade
  • HCH, technical grade [Hexachlorocyclohexanes]
  • Hexachlorocyclohexane, gamma isomer
  • Hexachlorocyclohexane, gamma-
  • Lindane
  • Lindane [Hexachlorocyclohexanes]
  • RCRA waste no. U129

Mixture Name

  • Kwell

Registry Numbers

CAS Registry Number

  • 58-89-9

FDA UNII

  • 59NEE7PCAB

Other Registry Numbers

  • 25897-48-7
  • 53529-37-6
  • 55963-79-6
  • 8007-42-9
  • 8073-23-2

System Generated Number

  • 0000058899

Structure Descriptors

InChI

1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+

InChIKey

JLYXXMFPNIAWKQ-GNIYUCBRSA-N

Smiles

[C@@H]1([C@@H]([C@@H]([C@H]([C@@H]([C@@H]1Cl)Cl)Cl)Cl)Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 25mg/kg (25mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 72, 1982.
cat LDLo unreported 50mg/kg (50mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Pharmacology and Toxicology. English translation of FATOAO. Vol. 22, Pg. 273, 1959.
child TDLo oral 111mg/kg (111mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Environmental Health. Vol. 25, Pg. 374, 1972.
child TDLo oral 180mg/kg (180mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
"Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.
dog LD50 oral 40mg/kg (40mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 11, 1978.
dog LDLo intravenous 7500ug/kg (7.5mg/kg)   Tieraerztliche Umschau. Vol. 5, Pg. 61, 1950.
guinea pig LD50 oral 127mg/kg (127mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 386, 1947.
hamster LD50 intraperitoneal 640mg/kg (640mg/kg)   Archives of Toxicology. Vol. 58, Pg. 152, 1986.
hamster LD50 oral 360mg/kg (360mg/kg)   European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974.
human LDLo oral 840mg/kg (840mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 1232, 1992.
mammal (species unspecified) LD50 unreported 300mg/kg (300mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(3), Pg. 32, 1973.
man TDLo skin 20mg/kg/6W-I (20mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

CARDIAC: OTHER CHANGES
American Journal of Diseases of Children. Vol. 141, Pg. 125, 1987.
mouse LCLo inhalation 120mg/m3/6H (120mg/m3) BLOOD: CHANGES IN OTHER CELL COUNT (UNSPECIFIED)

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 8(10), Pg. 55, 1964.
mouse LD50 intracrebral 60mg/kg (60mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toxicology Letters. Vol. 60, Pg. 289, 1992.
mouse LD50 intraperitoneal 125mg/kg (125mg/kg)   Soviet Genetics. English translation of GNKAA5. Vol. 2, Pg. 80, 1966.
mouse LD50 oral 44mg/kg (44mg/kg)   Journal of Economic Entomology. Vol. 65, Pg. 632, 1972.
rabbit LD50 oral 60mg/kg (60mg/kg)   Journal of Hygiene, Epidemiology, Microbiology, and Immunology. Vol. 22, Pg. 115, 1978.
rabbit LD50 skin 50mg/kg (50mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Quarterly Bulletin--Association of Food and Drug Officials of the United States. Vol. 16, Pg. 3, 1952.
rabbit LDLo intravenous 4500ug/kg (4.5mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 140, 1948.
rat LD50 intraperitoneal 35mg/kg (35mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 212, Pg. 463, 1951.
rat LD50 oral 76mg/kg (76mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 11, 1978.
rat LD50 skin 414mg/kg (414mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(7), Pg. 87, 1990.
rat LD50 unreported 125mg/kg (125mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 28(8), Pg. 29, 1963.
rat LD50 unreported 125mg/kg (125mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 28(8), Pg. 29, 1963.
women TDLo skin 19mg/kg/1H-I (19mg/kg) BEHAVIORAL: EXCITEMENT

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Annals of Emergency Medicine. Vol. 24, Pg. 972, 1994.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 112.5 deg C   EXP
Boiling Point 323.4 deg C   EXP
log P (octanol-water) 3.72 (none)   EXP
Water Solubility 7.3 mg/L 25 EXP
Vapor Pressure 4.20E-05 mm Hg 20 EXP
Henry's Law Constant 5.14E-06 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.90E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.