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Substance Name: Chlorothiazide [USP:INN:BAN]
RN: 58-94-6
UNII: 77W477J15H
InChIKey: JBMKAUGHUNFTOL-UHFFFAOYSA-N

Note

  • A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

Molecular Formula

  • C7-H6-Cl-N3-O4-S2

Molecular Weight

  • 295.726
 

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Mutation Data
  • Natriuretic Agents
  • Reproductive Effect
  • Sodium Chloride Symporter Inhibitors

Names and Synonyms

Name of Substance

  • Chlorothiazide
  • Chlorothiazide [USP:INN:BAN]

MeSH Heading

  • Chlorothiazide

Synonyms

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
  • 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • Alurene
  • CCRIS 5999
  • Chlorosal
  • Chlorothiazid
  • Chlorothiazide
  • Chlorothiazidum
  • Chlorothiazidum [INN-Latin]
  • Chlorthiazid
  • Chlorthiazide
  • Chlorthiazidum
  • Chlortiazid
  • Chlorurit
  • Chlotride
  • Clorotiazida
  • Clorotiazida [INN-Spanish]
  • Clorotiazide
  • Clorotiazide [DCIT]
  • Clotride
  • Diuresal
  • Diuril
  • Diuril Boluses, Veterinary
  • Diurilix
  • Diurite
  • Diutrid
  • EINECS 200-404-9
  • Flumen
  • HSDB 3030
  • Minzil
  • Neo-dema
  • NSC 25693
  • Salisan
  • Salunil
  • Saluretil
  • Saluric
  • SK-Chlorothiazide
  • Thiazide
  • UNII-77W477J15H
  • Urinex
  • Warduzide
  • Yadalan

Systematic Names

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
  • Chlorothiazide

Mixture Names

  • Aldoclor
  • Diupres

Registry Numbers

CAS Registry Number

  • 58-94-6

FDA UNII

  • 77W477J15H

System Generated Number

  • 0000058946

Structure Descriptors

InChI

1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

InChIKey

JBMKAUGHUNFTOL-UHFFFAOYSA-N

Smiles

c12c(cc(Cl)c(c1)S(N)(=O)=O)N=CNS2(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 1gm/kg (1000mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 77, 1973.
mouse LD50 intraperitoneal 1400mg/kg (1400mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
mouse LD50 intravenous 940mg/kg (940mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
mouse LD50 oral 8gm/kg (8000mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 467, 1959.
rat LD50 intraperitoneal 1386mg/kg (1386mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 77, 1973.
rat LD50 intravenous 200mg/kg (200mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 333, 1959.
rat LD50 oral 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 350 dec deg C   EXP
pKa Dissociation Constant 6.85 (none)   EXP
log P (octanol-water) -0.24 (none)   EXP
Water Solubility 266 mg/L 30 EXP
Vapor Pressure 2.09E-11 mm Hg 25 EST
Henry's Law Constant 4.05E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.81E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.