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Substance Name: Metiapine [USAN:INN]
RN: 5800-19-1
UNII: 775D6D91J8
InChIKey: IOEPXYJOHIZYGQ-UHFFFAOYSA-N

Classification Codes

  • Antipsychotic
  • Reproductive Effect

Molecular Formula

  • C19-H21-N3-S

Molecular Weight

  • 323.4619
 
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Names and Synonyms

Name of Substance

  • Metiapine
  • Metiapine [USAN:INN]

Synonyms

  • 2-Methyl-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine
  • BRN 0833849
  • Dibenzo(b,f)(1,4)thiazepine, 2-methyl-11-(4-methyl-1-piperazinyl)-
  • Metiapina
  • Metiapina [INN-Spanish]
  • Metiapine
  • Metiapinum
  • Metiapinum [INN-Latin]
  • UNII-775D6D91J8

Systematic Name

  • Dibenzo(b,f)(1,4)thiazepine, 2-methyl-11-(4-methyl-1-piperazinyl)-

Registry Numbers

CAS Registry Number

  • 5800-19-1

FDA UNII

  • 775D6D91J8

System Generated Number

  • 0005800191

Structure Descriptors

InChI

1S/C19H21N3S/c1-14-7-8-17-15(13-14)19(22-11-9-21(2)10-12-22)20-16-5-3-4-6-18(16)23-17/h3-8,13H,9-12H2,1-2H3

InChIKey

IOEPXYJOHIZYGQ-UHFFFAOYSA-N

Smiles

Cc1ccc2c(c1)C(=Nc3ccccc3S2)N4CCN(CC4)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 320mg/kg (320mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 25, Pg. 220, 1973.
mouse LD50 oral 680mg/kg (680mg/kg)   Toxicology and Applied Pharmacology. Vol. 22, Pg. 334, 1972.
rat LD50 intraperitoneal 487mg/kg (487mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 25, Pg. 220, 1973.
rat LD50 oral 934mg/kg (934mg/kg)   Toxicology and Applied Pharmacology. Vol. 22, Pg. 334, 1972.